Absence of the transcription factor E2F1 attenuates brain injury and improves behavior after focal ischemia in mice (Q44584348)

4 December 2017

Absence of the transcription factor E2F1 attenuates brain injury and improves behavior after focal ischemia in mice (English)

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4 December 2017

John P MacManus

1

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4 December 2017

Ming Jian

2

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4 December 2017

Edward Preston

3

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4 December 2017

Ingrid Rasquinha

4

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4 December 2017

Jackie Webster

5

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4 December 2017

Bogdan Zurakowski

6

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4 December 2017

1 September 2003

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Journal of Cerebral Blood Flow & Metabolism

4 December 2017

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4 December 2017

23

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4 December 2017

9

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4 December 2017

1020-1028

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https://scigraph.springernature.com/pub.10.1097/01.wcb.0000084249.20114.fa

4 December 2017

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Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis?

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Attenuation of neurotoxicity in cortical cultures and hippocampal slices from E2F1 knockout mice.

21 January 2018

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E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3.

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The transcription factor E2F1 promotes dopamine-evoked neuronal apoptosis by a mechanism independent of transcriptional activation

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Increased expression of the transcription factor E2F1 during dopamine-evoked, caspase-3-mediated apoptosis in rat cortical neurons

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Molecular mechanisms of cerebral ischemia-induced neuronal death.

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Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis

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E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

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Effects of an Rb mutation in the mouse

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Microarray analysis of hippocampal gene expression in global cerebral ischemia

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Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

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Immunoreactivity of cyclin D1/cdk4 in neurons and oligodendrocytes after focal cerebral ischemia in rat.

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Decreased brain infarct following focal ischemia in mice lacking the transcription factor E2F1.

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Alterations of Bcl-2 family proteins precede cytoskeletal proteolysis in the penumbra, but not in infarct centres following focal cerebral ischemia in mice.

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Up-regulation of E2F-1 in Down's syndrome brain exhibiting neuropathological features of Alzheimer-type dementia

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E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

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Cyclin-dependent kinases as a therapeutic target for stroke.

21 January 2018

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Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

21 January 2018

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E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways

21 January 2018

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21 January 2018

E2F-1 induced apoptosis

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Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.

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E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis

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Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia

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DNA microarray analysis of cortical gene expression during early recirculation after focal brain ischemia in rat.

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Characterization of cyclin D1 expression in a rat global model of cerebral ischemia

21 January 2018

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Parallel gene expression monitoring using oligonucleotide probe arrays of multiple transcripts with an animal model of focal ischemia

21 January 2018

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Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia.

21 January 2018

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Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death?

21 January 2018

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The identification of E2F1-specific target genes

21 January 2018

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E2F1 selects tumour cells for both life and death

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DNA cleavage and proteolysis of microtubule-associated protein 2 after cerebral ischemia of different severity.

21 January 2018

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Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment

21 January 2018

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Neurological impairment in rats after transient middle cerebral artery occlusion: a comparative study under various treatment paradigms

21 January 2018

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10.1097/01.WCB.0000084249.20114.FA

21 January 2018

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DOI

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Dimensions Publication ID

4 December 2017

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