Basic residues in the 37-loop of activated protein C modulate inhibition by protein C inhibitor but not by alpha(1)-antitrypsin (Q44485288)

3 December 2017

Basic residues in the 37-loop of activated protein C modulate inhibition by protein C inhibitor but not by alpha(1)-antitrypsin (English)

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3 December 2017

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Laura N Glasscock

1

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3 December 2017

Bruce Gerlitz

2

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3 December 2017

Scott T Cooper

3

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3 December 2017

Brian W Grinnell

4

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3 December 2017

Frank C Church

5

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3 December 2017

1 June 2003

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Biochimica et Biophysica Acta

3 December 2017

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3 December 2017

1649

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3 December 2017

106-117

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3 December 2017

1

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The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

3 December 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Intermolecular interactions between protein C inhibitor and coagulation proteases

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Protein C inhibitor is a potent inhibitor of the thrombin-thrombomodulin complex

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Interaction of activated protein C with serpins

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Rapid inhibition of the sperm protease acrosin by protein C inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Protein C inhibitor secreted from activated platelets efficiently inhibits activated protein C on phosphatidylethanolamine of platelet membrane and microvesicles

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Assessment of the interaction between urokinase and reactive site mutants of protein C inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Protein C inhibitor may modulate human sperm-oocyte interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Efficacy and safety of recombinant human activated protein C for severe sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Activated protein C directly activates human endothelial gelatinase A

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Thrombin-thrombomodulin activation of protein C facilitates the activation of progelatinase A.

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Plasminogen activator inhibitor-1 and -3 increase cell adhesion and motility of MDA-MB-435 breast cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Contribution of basic residues of the D and H helices in heparin binding to protein C inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Heparin binding of protein-C inhibitor--analysis of the effect of heparin on the interaction of protein-C inhibitor with tissue kallikrein

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Selective screening of a large phage display library of plasminogen activator inhibitor 1 mutants to localize interaction sites with either thrombin or the variable region 1 of tissue-type plasminogen activator.

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Variants of tissue-type plasminogen activator that display extraordinary resistance to inhibition by the serpin plasminogen activator inhibitor type 1.

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Introduction of an RRHR motif into chicken urokinase-type plasminogen activator (ch-uPA) confers sensitivity to plasminogen activator inhibitor (PAI)-1 and PAI-2 and allows ch-uPA-mediated extracellular matrix degradation to be controlled by PAI-1

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Role of thrombin anion-binding exosite-I in the formation of thrombin-serpin complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

The nucleotide sequence of the gene for human protein C

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Isolation and Characterization of a Mouse Protein C cDNA

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Mutation of protease domain residues Lys37-39 in human protein C inhibits activation by the thrombomodulin-thrombin complex without affecting activation by free thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Structural and energetic characteristics of the heparin-binding site in antithrombotic protein C.

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Contribution of basic residues of the 70-80-loop to heparin binding and anticoagulant function of activated protein C.

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Enhancement of heparin cofactor II anticoagulant activity

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Protein C inhibitor: purification and proteinase reactivity

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Deficiency of protein C inhibitor in combined factor V/VIII deficiency disease

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

The glycosaminoglycans of human plasma

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Vitronectin functions as a cofactor for rapid inhibition of activated protein C by plasminogen activator inhibitor-1. Implications for the mechanism of profibrinolytic action of activated protein C

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C.

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Secondary substrate-binding exosite in the serine protease domain of activated protein C important for cleavage at Arg-506 but not at Arg-306 in factor Va.

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Molecular modeling of protein-glycosaminoglycan interactions.

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processes

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

The 2.8 A crystal structure of Gla-domainless activated protein C

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Purification and characterization of plasma protein C inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Crystal structure of protein C inhibitor provides insights into hormone binding and heparin activation

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Inhibitory mechanism of serpins. Mobility of the C-terminal region of the reactive-site loop

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Major proteinase movement upon stable serpin-proteinase complex formation

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Intrinsic specificity of the reactive site loop of alpha1-antitrypsin, alpha1-antichymotrypsin, antithrombin III, and protease nexin I

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Arginine 200 of heparin cofactor II promotes intramolecular interactions of the acidic domain. Implication for thrombin inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Effect of oligodeoxynucleotide thrombin aptamer on thrombin inhibition by heparin cofactor II and antithrombin

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Aspartic acid residues 72 and 75 and tyrosine-sulfate 73 of heparin cofactor II promote intramolecular interactions during glycosaminoglycan binding and thrombin inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

Immunoblotting studies of the molecular forms of protein C in plasma

1 reference

https://api.crossref.org/works/10.1016%2FS1570-9639%2803%2900164-X

7 January 2021

10.1016/S1570-9639(03)00164-X

Identifiers

DOI

1 reference

3 December 2017

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