Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy (Q44446014)

3 December 2017

Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy (English)

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3 December 2017

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2

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3 December 2017

8

Gen Sobue

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3 December 2017

Masahisa Katsuno

1

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3 December 2017

Manabu Doyu

3

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3 December 2017

Makoto Minamiyama

4

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3 December 2017

Chen Sang

5

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3 December 2017

Yasushi Kobayashi

6

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3 December 2017

Akira Inukai

7

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3 December 2017

language of work or name

English

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publication date

18 May 2003

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3 December 2017

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3 December 2017

9

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3 December 2017

768-773

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3 December 2017

6

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https://scigraph.springernature.com/pub.10.1038/nm878

3 December 2017

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cites work

Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex-linked recessive trait

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Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

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Severity of X-linked recessive bulbospinal neuronopathy correlates with size of the tandem CAG repeat in androgen receptor gene

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Glutamine repeats and neurodegeneration

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Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy.

21 January 2018

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Nonneural nuclear inclusions of androgen receptor protein in spinal and bulbar muscular atrophy

21 January 2018

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Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

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Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

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Mechanism of action and pure antiandrogenic properties of flutamide

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Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

21 January 2018

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The subnuclear three-dimensional image analysis of androgen receptor fused to green fluorescence protein

21 January 2018

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Ligand promotes intranuclear inclusions in a novel cell model of spinal and bulbar muscular atrophy

21 January 2018

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Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.

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Androgen receptor mutation in Kennedy's disease

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Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor

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Androgen insensitivity.

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Defects of androgen receptor function: from sex reversal to motor neurone disease

21 January 2018

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Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

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Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

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Histone deacetylase inhibitors reduce polyglutamine toxicity

21 January 2018

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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

21 January 2018

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Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

21 January 2018

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Efficient selection for high-expression transfectants with a novel eukaryotic vector

21 January 2018

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Transgenic mice with an expanded CAG repeat controlled by the human AR promoter show polyglutamine nuclear inclusions and neuronal dysfunction without neuronal cell death

21 January 2018

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Daily dosing with flutamide or Casodex exerts maximal antiandrogenic activity

21 January 2018

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Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

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Altered acetylation in polyglutamine disease: an opportunity for therapeutic intervention?

21 January 2018

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X-linked recessive bulbospinal neuronopathy. A clinicopathological study

21 January 2018

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7 January 2021

Subclinical phenotypic expressions in heterozygous females of X-linked recessive bulbospinal neuronopathy

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7 January 2021

Phenotypic manifestations associated with CAG-repeat expansion in the androgen receptor gene in male patients and heterozygous females: a clinical and molecular study of 30 families

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7 January 2021

Expression of X-linked bulbospinal muscular atrophy (Kennedy disease) in two homozygous women

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7 January 2021

Founder effect in spinal and bulbar muscular atrophy (SBMA)

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7 January 2021

Strong correlation between the number of CAG repeats in androgen receptor genes and the clinical onset of features of spinal and bulbar muscular atrophy

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7 January 2021

Agonist and antagonist activities of hydroxyflutamide and casodex relate to androgen receptor stabilization

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7 January 2021

Neural androgen receptor regulation: effects of androgen and antiandrogen

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7 January 2021

Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract

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7 January 2021

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

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7 January 2021

Caspase-3 cleaves the expanded androgen receptor protein of spinal and bulbar muscular atrophy in a polyglutamine repeat length-dependent manner

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7 January 2021

Identifiers

DOI

10.1038/NM878

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Dimensions Publication ID

3 December 2017

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