Glibenclamide inhibits islet carnitine palmitoyltransferase 1 activity, leading to PKC-dependent insulin exocytosis (Q44396052)

2 December 2017

title

Glibenclamide inhibits islet carnitine palmitoyltransferase 1 activity, leading to PKC-dependent insulin exocytosis (English)

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2 December 2017

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3

Per-Olof Berggren

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2 December 2017

Mikael Lehtihet

1

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2 December 2017

Nils Welsh

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2

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2 December 2017

George A Cook

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4

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2 December 2017

Ake Sjoholm

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5

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2 December 2017

publication date

8 April 2003

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American Journal of Physiology - Endocrinology and Metabolism

2 December 2017

published in

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2 December 2017

volume

285

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2 December 2017

issue

2

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2 December 2017

page(s)

E438-46

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Stimulation of islet protein kinase C translocation by palmitate requires metabolism of the fatty acid.

2 December 2017

cites work

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Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells.

21 January 2018

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Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1.

21 January 2018

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Fasting hypoglycemia resulting from hepatic carnitine palmitoyl transferase deficiency.

21 January 2018

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More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling

21 January 2018

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Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells).

21 January 2018

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Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration

21 January 2018

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Critical role for cataplerosis via citrate in glucose-regulated insulin release

21 January 2018

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Rationale and application of fatty acid oxidation inhibitors in treatment of diabetes mellitus

21 January 2018

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Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells

21 January 2018

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Method for Large-Scale Isolation of Pancreatic Islets by Tissue Culture of Fetal Rat Pancreas

21 January 2018

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Effects and serum levels of glibenclamide and its active metabolites in patients with type 2 diabetes

21 January 2018

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Impact of CYP2C9 amino acid polymorphisms on glyburide kinetics and on the insulin and glucose response in healthy volunteers

21 January 2018

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21 January 2018

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Untersuchungen uber die Harnstoffbildung im Tierkörper

21 January 2018

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21 January 2018

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21 January 2018

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Production of phosphatidylethanol by phospholipase D phosphatidyl transferase in intact or dispersed pancreatic islets: evidence for the in situ metabolism of phosphatidylethanol

21 January 2018

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Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes

21 January 2018

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Sulfonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+ channel-independent action

21 January 2018

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Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion

21 January 2018

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Aspects of novel sites of regulation of the insulin stimulus-secretion coupling in normal and diabetic pancreatic islets

21 January 2018

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Sulfonylureas enhance exocytosis from pancreatic beta-cells by a mechanism that does not involve direct activation of protein kinase C.

21 January 2018

1 reference

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10.1152/AJPENDO.00057.2003

21 January 2018

Identifiers

DOI

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2 December 2017

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