Do T cells need endogenous peptides for activation? (Q44376899)

2 December 2017

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title

Do T cells need endogenous peptides for activation? (English)

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2 December 2017

Nicholas R J Gascoigne

series ordinal

1

object named as

Nicholas R J Gascoigne

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2 December 2017

1 November 2008

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Nature Reviews Immunology

2 December 2017

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2 December 2017

8

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2 December 2017

11

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2 December 2017

895-900

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https://scigraph.springernature.com/pub.10.1038/nri2431

2 December 2017

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cites work

CD4 dimers constitute the functional component required for T cell activation

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Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement

21 January 2018

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Direct observation of ligand recognition by T cells.

21 January 2018

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Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]

31 March 2020

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The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers

31 March 2020

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Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers

31 March 2020

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Receptor proximity, not intermolecular orientation, is critical for triggering T-cell activation

31 March 2020

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CD8+ cytotoxic T lymphocyte activation by soluble major histocompatibility complex-peptide dimers

31 March 2020

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CD8 Expression Allows T Cell Signaling by Monomeric Peptide-MHC Complexes

31 March 2020

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T cell adhesion lowers the threshold for antigen detection

31 March 2020

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The beta1 and beta3 integrins promote T cell receptor-mediated cytotoxic T lymphocyte activation

31 March 2020

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Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity

31 March 2020

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Erratum: Costimulation and endogenous MHC ligands contribute to T cell recognition

31 March 2020

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Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

31 March 2020

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Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity

31 March 2020

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Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse

31 March 2020

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T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state

31 March 2020

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Empty MHC class I molecules come out in the cold

31 March 2020

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Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response

31 March 2020

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Self peptide/MHC class I complexes have a negligible effect on the response of some CD8+ T cells to foreign antigen

31 March 2020

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Modeling T cell antigen discrimination based on feedback control of digital ERK responses

31 March 2020

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HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation

31 March 2020

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HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

31 March 2020

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Molecular interactions mediating T cell antigen recognition

31 March 2020

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How TCRs bind MHCs, peptides, and coreceptors

31 March 2020

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Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2

31 March 2020

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Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule

31 March 2020

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Dimeric association and segmental variability in the structure of human CD4

31 March 2020

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Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes

31 March 2020

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Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: the role of CD4 coreceptor

31 March 2020

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CD8 kinetically promotes ligand binding to the T-cell antigen receptor.

31 March 2020

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Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse

31 March 2020

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T-cell-receptor affinity and thymocyte positive selection

31 March 2020

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Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

31 March 2020

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A constant affinity threshold for T cell tolerance

31 March 2020

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Increased mobility of major histocompatibility complex I-peptide complexes decreases the sensitivity of antigen recognition

31 March 2020

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How T cells 'see' antigen

31 March 2020

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Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

31 March 2020

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Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8.

31 March 2020

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Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions

31 March 2020

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Hijacking and exploitation of IL-10 by intracellular pathogens

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31 March 2020

Identifiers

DOI

10.1038/NRI2431

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PubMed ID

18846098

Dimensions Publication ID

2 December 2017

0 references

1 reference

PubMed ID

18846098