TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways (Q44308973)

1 December 2017

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways (English)

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1 December 2017

6

Ronald N Germain

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1 December 2017

Irena Stefanová

1

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1 December 2017

Bernhard Hemmer

2

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1 December 2017

Marco Vergelli

3

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1 December 2017

Roland Martin

4

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1 December 2017

William E Biddison

5

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1 December 2017

language of work or name

English

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publication date

10 February 2003

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1 December 2017

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1 December 2017

4

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1 December 2017

248-254

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1 December 2017

3

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The biochemistry and cell biology of antigen processing and presentation

1 December 2017

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7 January 2021

Kinetic proofreading in T-cell receptor signal transduction

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7 January 2021

T cell receptor antagonists and partial agonists

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7 January 2021

Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation

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7 January 2021

Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy

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7 January 2021

Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists

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7 January 2021

Partial signaling by CD8+ T cells in response to antagonist ligands

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7 January 2021

Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation

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7 January 2021

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

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7 January 2021

Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells

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7 January 2021

Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling

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7 January 2021

T cell receptor (TCR) antagonism without a negative signal: evidence from T cell hybridomas expressing two independent TCRs

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7 January 2021

Cross-antagonism of a T cell clone expressing two distinct T cell receptors

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7 January 2021

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

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7 January 2021

Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling

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7 January 2021

Altered T cell receptor ligands trigger a subset of early T cell signals

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7 January 2021

Kinetics and extent of T cell activation as measured with the calcium signal

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7 January 2021

Hematopoietic cell phosphatase (HCP) regulates p56LCK phosphorylation and ZAP-70 binding to T cell receptor zeta chain

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7 January 2021

Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase

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7 January 2021

Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells

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7 January 2021

SH2 domains recognize specific phosphopeptide sequences

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7 January 2021

Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck

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7 January 2021

Modification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain

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7 January 2021

Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical

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7 January 2021

Selective events in T cell development

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7 January 2021

Antigen analogs/MHC complexes as specific T cell receptor antagonists

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7 January 2021

Selective activation of the calcium signaling pathway by altered peptide ligands

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7 January 2021

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness

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7 January 2021

T-cell-receptor affinity and thymocyte positive selection

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7 January 2021

A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists

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7 January 2021

Delineation of a T-cell activation motif required for binding of protein tyrosine kinases containing tandem SH2 domains

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7 January 2021

Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif

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7 January 2021

Supra-agonist peptides enhance the reactivation of memory CTL responses.

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7 January 2021

Erratum: Costimulation and endogenous MHC ligands contribute to T cell recognition

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7 January 2021

The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes

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7 January 2021

Receptor clustering as a cellular mechanism to control sensitivity

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7 January 2021

Cooperative enhancement of specificity in a lattice of T cell receptors

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7 January 2021

Selective requirement for MAP kinase activation in thymocyte differentiation.

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7 January 2021

Positive and negative selection invoke distinct signaling pathways.

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7 January 2021

The influence of the MAPK pathway on T cell lineage commitment

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7 January 2021

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate.

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7 January 2021

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

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7 January 2021

Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases

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7 January 2021

Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway

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7 January 2021

NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk

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7 January 2021

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice

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7 January 2021

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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7 January 2021

Analysis of the T-cell receptor repertoire of human T-cell leukemia virus type 1 (HTLV-1) Tax-specific CD8+ cytotoxic T lymphocytes from patients with HTLV-1-associated disease: evidence for oligoclonal expansion

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7 January 2021

Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.

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7 January 2021

Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation

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7 January 2021

Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death

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7 January 2021

Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells

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7 January 2021

Identifiers

DOI

10.1038/NI895

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1 December 2017

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