Pegylated TRAIL retains anti-leukemic cytotoxicity and exhibits improved signal transduction activity with respect to TRAIL. (Q44230417)

1 December 2017

Pegylated TRAIL retains anti-leukemic cytotoxicity and exhibits improved signal transduction activity with respect to TRAIL. (English)

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1 December 2017

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3

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5

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1 December 2017

Arianna Gonelli

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author name string

Oriano Radillo

series ordinal

2

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PubMed ID

21125311

1 December 2017

Erika Rimondi

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4

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PubMed ID

21125311

1 December 2017

Gian Maria Bonora

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6

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1 December 2017

2 December 2010

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Investigational New Drugs

1 December 2017

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1 December 2017

30

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1 December 2017

828-832

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1 December 2017

2

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https://scigraph.springernature.com/pub.10.1007/s10637-010-9599-8

1 December 2017

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Activated human NK and CD8+ T cells express both TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors but are resistant to TRAIL-mediated cytotoxicity

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Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells

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An increased osteoprotegerin serum release characterizes the early onset of diabetes mellitus and may contribute to endothelial cell dysfunction

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Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells.

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Site-specific PEGylation of a lysine-deficient TNF-alpha with full bioactivity

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TRAIL promotes the survival, migration and proliferation of vascular smooth muscle cells

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Tissue distribution, stability, and pharmacokinetics of Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in human colon carcinoma COLO205 tumor-bearing nude mice

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Phase 1b Study of Dulanermin (recombinant human Apo2L/TRAIL) in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Patients With Advanced Non-Squamous Non–Small-Cell Lung Cancer

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Tumour necrosis factor-related apoptosis-inducing ligand sequentially activates pro-survival and pro-apoptotic pathways in SK-N-MC neuronal cells

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Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: characterization of in vivo efficacy, pharmacokinetics, and safety

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TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release

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Extracellular HIV-1 Tat protein induces the rapid Ser133 phosphorylation and activation of CREB transcription factor in both Jurkat lymphoblastoid T cells and primary peripheral blood mononuclear cells

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Uninfected haematopoietic progenitor (CD34+) cells purified from the bone marrow of AIDS patients are committed to apoptotic cell death in culture

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10.1007/S10637-010-9599-8

Identifiers

DOI

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1 December 2017

1 reference

PubMed ID

21125311