Inhibitor binding alters the directions of domain motions in HIV-1 reverse transcriptase (Q44125142)

30 November 2017

Inhibitor binding alters the directions of domain motions in HIV-1 reverse transcriptase (English)

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30 November 2017

2

Ivet Bahar

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author name string

N Alpay Temiz

series ordinal

1

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PubMed ID

12211016

30 November 2017

language of work or name

English

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publication date

1 October 2002

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30 November 2017

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30 November 2017

49

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30 November 2017

1

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30 November 2017

61-70

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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

30 November 2017

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Structure of HIV-1 reverse transcriptase/DNA complex at 7 A resolution showing active site locations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-[Spiro[4"-amino-2",2" -dioxo-1",2" -oxathiole-5",3'-[2', 5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]]]-3-ethylthy mine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Ab initio molecular dynamics studies on HIV-1 reverse transcriptase triphosphate binding site: implications for nucleoside-analog drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Prediction of the binding free energies of new TIBO-like HIV-1 reverse transcriptase inhibitors using a combination of PROFEC, PB/SA, CMC/MD, and free energy calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Use of MM-PBSA in reproducing the binding free energies to HIV-1 RT of TIBO derivatives and predicting the binding mode to HIV-1 RT of efavirenz by docking and MM-PBSA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Statistical Thermodynamics of Random Networks [and Discussion]

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Direct evaluation of thermal fluctuations in proteins using a single-parameter harmonic potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Gaussian Dynamics of Folded Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Correlation between native-state hydrogen exchange and cooperative residue fluctuations from a simple model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Structure-based analysis of protein dynamics: comparison of theoretical results for hen lysozyme with X-ray diffraction and NMR relaxation data

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Vibrational Dynamics of Folded Proteins: Significance of Slow and Fast Motions in Relation to Function and Stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Vibrational dynamics of transfer RNAs: comparison of the free and synthetase-bound forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Cooperative fluctuations and subunit communication in tryptophan synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Identification of kinetically hot residues in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Collective motions in HIV-1 reverse transcriptase: examination of flexibility and enzyme function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Anisotropy of fluctuation dynamics of proteins with an elastic network model

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Investigating protein dynamics in collective coordinate space

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Efficient sampling in collective coordinate space.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Collective protein dynamics in relation to function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Relationships between protein structure and dynamics from a database of NMR-derived backbone order parameters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Dynamic activation of protein function: a view emerging from NMR spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Dynamics and function of proteins: the search for general concepts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

A dynamic model for the allosteric mechanism of GroEL

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Harmonic dynamics of proteins: normal modes and fluctuations in bovine pancreatic trypsin inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Dynamics of a small globular protein in terms of low-frequency vibrational modes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Protein normal-mode dynamics: trypsin inhibitor, crambin, ribonuclease and lysozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Essential dynamics of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Enzyme specificity under dynamic control: a normal mode analysis of alpha-lytic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Conformational change of proteins arising from normal mode calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Analysis of the low frequency normal modes of the T-state of aspartate transcarbamylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Domain motions in bacteriophage T4 lysozyme: a comparison between molecular dynamics and crystallographic data.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Investigation of the mechanism of domain closure in citrate synthase by molecular dynamics simulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Functional motions of influenza virus hemagglutinin: a structure-based analytical approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Molecular mechanisms of chaperonin GroEL-GroES function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Analysis of domain motions by approximate normal mode calculations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Point mutations and sequence variability in proteins: redistributions of preexisting populations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Inter-residue potentials in globular proteins and the dominance of highly specific hydrophilic interactions at close separation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Molecular dynamics of HIV-1 reverse transcriptase indicates increased flexibility upon DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

The thumb domain of the P51-subunit is essential for activation of HIV reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Temperature-dependent equilibrium between the open and closed conformation of the p66 subunit of HIV-1 reverse transcriptase revealed by site-directed spin labelling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Structure-based design of non-nucleoside reverse transcriptase inhibitors of drug-resistant human immunodeficiency virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Proteins with similar architecture exhibit similar large-scale dynamic behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

Loss of polymerase activity due to Tyr to Phe substitution in the YMDD motif of human immunodeficiency virus type-1 reverse transcriptase is compensated by Met to Val substitution within the same motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

High resolution structures of HIV-1 RT from four RT-inhibitor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

The essential dynamics of thermolysin: Confirmation of the hinge-bending motion and comparison of simulations in vacuum and water

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.10183

21 January 2018

Identifiers

DOI

10.1002/PROT.10183

1 reference

release_utlqygv4kvejbokvwrvswfgjdy

30 November 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/utlqygv4kvejbokvwrvswfgjdy

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24 November 2022

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PubMed ID

12211016

1 reference

PubMed ID

12211016