Curcumin disrupts mitotic spindle structure and induces micronucleation in MCF-7 breast cancer cells (Q44026767)

29 November 2017

Curcumin disrupts mitotic spindle structure and induces micronucleation in MCF-7 breast cancer cells (English)

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29 November 2017

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Jon M Holy

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PubMed ID

12063069

29 November 2017

language of work or name

English

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publication date

1 June 2002

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29 November 2017

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29 November 2017

518

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29 November 2017

1

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29 November 2017

71-84

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Antioxidant activity of curcumin and related compounds

29 November 2017

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Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis

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Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation

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Inhibition of proliferation and apoptosis of human and rat T lymphocytes by curcumin, a curry pigment

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Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53.

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Curcumin and genistein, plant natural products, show synergistic inhibitory effects on the growth of human breast cancer MCF-7 cells induced by estrogenic pesticides.

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Differential sensitivity of human mammary epithelial and breast carcinoma cell lines to curcumin

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Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway

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Quantitation of chemopreventive synergism between (-)-epigallocatechin-3-gallate and curcumin in normal, premalignant and malignant human oral epithelial cells

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Inhibition of neutrophil response by curcumin

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Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats

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Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation

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Stimulatory effect of curcumin on osteoclast apoptosis

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Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines

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Curcumin induces a p53-dependent apoptosis in human basal cell carcinoma cells

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Enhanced apoptosis mediates inhibition of EBV-transformed lymphoblastoid cell line proliferation by curcumin

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A novel apoptosis-like pathway, independent of mitochondria and caspases, induced by curcumin in human lymphoblastoid T (Jurkat) cells.

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Potent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats

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Curcumin exerts multiple suppressive effects on human breast carcinoma cells

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New colorimetric cytotoxicity assay for anticancer-drug screening

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Inhibitory effect of curcuminoids on MCF-7 cell proliferation and structure-activity relationships

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Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin

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Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells

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Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin.

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Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]

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L-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosis

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Suppression of transcription factor Egr-1 by curcumin

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Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells

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Protein kinase C signaling and oxidative stress

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Curcumin inhibits the proliferation and cell cycle progression of human umbilical vein endothelial cell

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Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon.

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Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis.

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Nonselective inhibition of proliferation of transformed and nontransformed cells by the anticancer agent curcumin (diferuloylmethane).

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Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

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A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity.

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7 January 2021

Microtubule-based motor function in mitosis

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Dissecting the role of molecular motors in the mitotic spindle

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Mutation of a gene that encodes a kinesin-like protein blocks nuclear division in A. nidulans

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Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly

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Mitotic spindle organization by a plus-end-directed microtubule motor

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Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

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The Xenopus laevis aurora/Ip11p-related kinase pEg2 participates in the stability of the bipolar mitotic spindle.

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The mitotic machinery as a source of genetic instability in cancer

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Potentiation by turmeric and curcumin of gamma-radiation-induced chromosome aberrations in Chinese hamster ovary cells

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The effect of retinoids, carotenoids and phenolics on chromosomal instability of bovine papillomavirus DNA-carrying cells

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Radiation-induced micronuclei formation in human breast cancer cells: dependence on serum and cell cycle distribution

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Identifiers

DOI

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29 November 2017

1 reference

PubMed ID

12063069