Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway (Q43940962)

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English	Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway	scientific article

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scholarly article

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Europe PubMed Central

28 November 2017

Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway (English)

1 reference

Europe PubMed Central

28 November 2017

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based on heuristic

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author name string

Ke Sai

1

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Europe PubMed Central

28 November 2017

Shuzhen Wang

2

1 reference

Europe PubMed Central

28 November 2017

Veerakumar Balasubramaniyan

3

1 reference

Europe PubMed Central

28 November 2017

Charles Conrad

4

1 reference

Europe PubMed Central

28 November 2017

Frederick F Lang

5

1 reference

Europe PubMed Central

28 November 2017

Kenneth Aldape

6

1 reference

Europe PubMed Central

28 November 2017

Slawomir Szymanski

7

1 reference

Europe PubMed Central

28 November 2017

Izabela Fokt

8

1 reference

Europe PubMed Central

28 November 2017

Atreyi Dasgupta

9

1 reference

Europe PubMed Central

28 November 2017

Timothy Madden

10

1 reference

Europe PubMed Central

28 November 2017

Su Guan

11

1 reference

Europe PubMed Central

28 November 2017

Zhongping Chen

12

1 reference

Europe PubMed Central

28 November 2017

W K Alfred Yung

13

1 reference

Europe PubMed Central

28 November 2017

Waldemar Priebe

14

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Europe PubMed Central

28 November 2017

Howard Colman

15

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Europe PubMed Central

28 November 2017

publication date

17 January 2012

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Europe PubMed Central

28 November 2017

Journal of Neuro-Oncology

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Europe PubMed Central

28 November 2017

107

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Europe PubMed Central

28 November 2017

487-501

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Europe PubMed Central

28 November 2017

3

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Europe PubMed Central

28 November 2017

https://scigraph.springernature.com/pub.10.1007/s11060-011-0786-z

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Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells

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Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

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Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

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Tie2-mediated multidrug resistance in malignant gliomas is associated with upregulation of ABC transporters

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Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

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Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

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Activation state EGFR and STAT-3 as prognostic markers in resected non-small cell lung cancer.

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Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

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Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells

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The transcriptional network for mesenchymal transformation of brain tumours.

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Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance

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STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells

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Stat3 activation is required for the growth of U87 cell-derived tumours in mice

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Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

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Inhibition of p-STAT3 enhances IFN-alpha efficacy against metastatic melanoma in a murine model.

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Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death

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Glioma-associated cancer-initiating cells induce immunosuppression

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An implantable guide-screw system for brain tumor studies in small animals.

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Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell.

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Retinal stem cells in the adult mammalian eye

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The MAPK signalling pathways and colorectal cancer

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Identification of human brain tumour initiating cells

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CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles.

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Stat3 as an oncogene

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p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

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Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

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Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy

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The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas.

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Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas

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Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor grade, and survival.

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Constitutive activation of Stat3alpha in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2).

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Notch signalling regulates stem cell numbers in vitro and in vivo

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Potentiation of astrogliogenesis by STAT3-mediated activation of bone morphogenetic protein-Smad signaling in neural stem cells

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WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells

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STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition

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Isolation of cancer stem cells from adult glioblastoma multiforme

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STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction

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Expression of signal transducers and activators of transcription proteins in acute myeloid leukemia blasts.

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12 December 2020

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Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells

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based on heuristic

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Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain tumor stem cells

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a cancer stem cell in human brain tumors

1 reference

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12 December 2020

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1 reference

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Immunology of spontaneous mammary carcinomas in mice. V. Acquired tumor resistance and enhancement in strain A mice infected with mammary tumor virus

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Analyzing mitochondrial changes during apoptosis

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12 December 2020

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10.1007/S11060-011-0786-Z

1 reference

Europe PubMed Central

28 November 2017

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24 November 2022

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Europe PubMed Central

28 November 2017

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