SN2 DNA-alkylating agent-induced phosphorylation of p53 and activation of p21 gene expression (Q43915766)

28 November 2017

title

SN2 DNA-alkylating agent-induced phosphorylation of p53 and activation of p21 gene expression (English)

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28 November 2017

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Aruna S Jaiswal

1

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28 November 2017

Satya Narayan

series ordinal

2

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28 November 2017

language of work or name

English

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publication date

1 March 2002

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28 November 2017

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28 November 2017

volume

500

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28 November 2017

issue

1-2

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28 November 2017

page(s)

17-30

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Activation of adenomatous polyposis coli (APC) gene expression by the DNA-alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine requires p53.

28 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

p53-dependent transcriptional regulation of the APC promoter in colon cancer cells treated with DNA alkylating agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Multisite phosphorylation and the integration of stress signals at p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

DNA damage activates p53 through a phosphorylation-acetylation cascade

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Human TAFII31 protein is a transcriptional coactivator of the p53 protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Phosphorylation of p53 serine 15 increases interaction with CBP

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

DNA damage induces phosphorylation of the amino terminus of p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

A role for ATR in the DNA damage-induced phosphorylation of p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Induction of direct and indirect single-strand breaks in human cell DNA by far- and near-ultraviolet radiations: action spectrum and mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Variations in Excision Repair of UVB-Induced Pyrimidine Dimers in DNA of Human Skin in Situ

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Ultraviolet light induces double-strand breaks in DNA of cultured human P3 cells as measured by neutral filter elution

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

DNA damage and mutagenesis induced by nitrogen mustards

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

APC mutations in colorectal tumors with mismatch repair deficiency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Requirement of mammalian DNA polymerase-beta in base-excision repair.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Self-destruction and tolerance in resistance of mammalian cells to alkylation damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Specificity of mutations induced by methyl methanesulfonate in mismatch repair-deficient human cancer cell lines.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Protection against methylation-induced cytotoxicity by DNA polymerase beta-dependent long patch base excision repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Mammalian base excision repair and DNA polymerase beta

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Two Pathways for Base Excision Repair in Mammalian Cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Physical interaction between components of DNA mismatch repair and nucleotide excision repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

WAF1, a potential mediator of p53 tumor suppression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Identification and analysis of all components of a gel retardation assay by combination with immunoblotting.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

p53 Phosphorylation at serine 15 is required for transcriptional induction of the plasminogen activator inhibitor-1 (PAI-1) gene by the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Allosteric activation of latent p53 tetramers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

A transcriptionally active DNA-binding site for human p53 protein complexes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Small peptides activate the latent sequence-specific DNA binding function of p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

A role for p53 in base excision repair.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Products of DNA mismatch repair genes mutS and mutL are required for transcription-coupled nucleotide-excision repair of the lactose operon in Escherichia coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Transcription-coupled repair deficiency and mutations in human mismatch repair genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Methylmethanesulfonate-induced DNA damage and its repair in cultured human fibroblasts: normal rates of induction and removal of alkali-labile sites in xeroderma pigmentosum (group A) cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Repression of p53-mediated transcription by MDM2: a dual mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

Two distinct signaling pathways activate the latent DNA binding function of p53 in a casein kinase II-independent manner.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900296-2

10.1016/S0027-5107(01)00296-2

7 January 2021

Identifiers

DOI

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28 November 2017

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