Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents. (Q30454407)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10485900%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

title

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents (English)

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31 October 2019

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1

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31 October 2019

author name string

L D Samson

series ordinal

2

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31 October 2019

publication date

1 September 1999

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Proceedings of the National Academy of Sciences of the United States of America

31 October 2019

language of work or name

English

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published in

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31 October 2019

volume

96

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31 October 2019

issue

19

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31 October 2019

page(s)

10764-10769

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Characterization of p53 in Chinese hamster cell lines CHO-K1, CHO-WBL, and CHL: implications for genotoxicity testing

31 October 2019

cites work

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Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine

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Isolation of MutSβ from Human Cells and Comparison of the Mismatch Repair Specificities of MutSβ and MutSα

28 July 2018

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Mismatch repair deficiency associated with overexpression of the MSH3 gene

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Functional Overlap in Mismatch Repair by Human MSH3 and MSH6

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A Chemical and Genetic Approach Together Define the Biological Consequences of 3-Methyladenine Lesions in the Mammalian Genome

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Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6

28 July 2018

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DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSα/hMutSβ ratio and reduces the efficiency of base–base mismatch repair

28 July 2018

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Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells

28 July 2018

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Cloning and characterization of Chinese hamster p53 cDNA.

28 July 2018

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Genomic instability and tolerance to alkylating agents.

28 July 2018

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hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

28 July 2018

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Replication across O6-methylguanine by human DNA polymerase beta in vitro. Insights into the futile cytotoxic repair and mutagenesis of O6-methylguanine

28 July 2018

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Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3.

28 July 2018

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hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA

28 July 2018

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Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair

28 July 2018

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Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct

28 July 2018

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Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest

28 July 2018

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Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent

28 July 2018

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Protein-DNA interactions at the major and minor promoters of the divergently transcribed dhfr and rep3 genes during the Chinese hamster ovary cell cycle

28 July 2018

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p53 is required for radiation-induced apoptosis in mouse thymocytes

28 July 2018

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Activation of cyclin A-dependent protein kinases during apoptosis

28 July 2018

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Apoptosis. Its significance in cancer and cancer therapy

28 July 2018

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An evolutionary perspective on apoptosis.

28 July 2018

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DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

28 July 2018

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Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo.

28 July 2018

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A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells

28 July 2018

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Hereditary Nonpolyposis Colorectal Cancer: the Syndrome, the Genes, and Historical Perspectives

28 July 2018

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Mutations of GTBP in genetically unstable cells

28 July 2018

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GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells

28 July 2018

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Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

28 July 2018

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Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine.

28 July 2018

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Comparison of O6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues

28 July 2018

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A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches

28 July 2018

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DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability

28 July 2018

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Oligonucleotide duplexes containing inosine, 7-deazainosine, tubercidin, nebularine and 7-deazanebularine as substrates for restriction endonucleases HindII, SalI and TaqI.

28 July 2018

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The initial physical damage produced by ionizing radiations

28 July 2018

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

28 July 2018

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Multiple origins of replication in the dihydrofolate reductase amplicons of a methotrexate-resistant chinese hamster cell line

28 July 2018

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DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal

28 July 2018

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Relative efficiencies of the bacterial, yeast, and human DNA methyltransferases for the repair of O6-methylguanine and O4-methylthymine. Suggestive evidence for O4-methylthymine repair by eukaryotic methyltransferases

28 July 2018

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Participation of p53 protein in the cellular response to DNA damage

28 July 2018

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p53 mutations in human cancers

28 July 2018

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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

28 July 2018

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Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

28 July 2018

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Activation of a mammalian origin of replication by chromosomal rearrangement

28 July 2018

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Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

28 July 2018

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

28 July 2018

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Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: Possibility for a rapid human cell mutation assay

28 July 2018

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Thymocyte apoptosis induced by p53-dependent and independent pathways

28 July 2018

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Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis

21 January 2018

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NF-kappa B activation by ultraviolet light not dependent on a nuclear signal.

21 January 2018

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Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting

21 January 2018

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An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

21 January 2018

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A hPMS2 mutant cell line is defective in strand-specific mismatch repair

21 January 2018

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The Chloroethylnitrosoureas: Sensitivity and Resistance to Cancer Chemotherapy at the Molecular Level

21 January 2018

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In vivo hprt mutant frequencies in T-cells of normal human newborns

21 January 2018

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Involvement of the Mismatch Repair System in Temozolomide-Induced Apoptosis

21 January 2018

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Predicting response to cancer chemotherapy: the role of p53

21 January 2018

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Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines.

21 January 2018

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Signalling by proteolysis: death receptors induce apoptosis

26 November 2018

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Repair of O6-methylguanine and O4-methylthymine by the human and rat O6-methylguanine-DNA methyltransferases

21 January 2018

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12 December 2020

Review:Death Domain Receptors and Their Role in Cell Demise

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12 December 2020

MSH3 deficiency is not sufficient for a mutator phenotype in Chinese hamster ovary cells

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12 December 2020

Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex−, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models

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12 December 2020

Processing of O6-methylguanine by mismatch correction in human cell extracts

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12 December 2020

O6-alkylguanine DNA lesions trigger apoptosis

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12 December 2020

p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha

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12 December 2020

Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates

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12 December 2020

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

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12 December 2020

Identifiers

DOI

10.1073/PNAS.96.19.10764

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10485900%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10485900%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

PubMed publication ID

10485900

1 reference