Disease modeling using embryonic stem cells: MeCP2 regulates nuclear size and RNA synthesis in neurons (Q43880632)

27 November 2017

Disease modeling using embryonic stem cells: MeCP2 regulates nuclear size and RNA synthesis in neurons (English)

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27 November 2017

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27 November 2017

Rubén Deogracias

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Adrian Peter Bird

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Adrian Bird

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author name string

Morteza Yazdani

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PubMed ID

22865604

27 November 2017

Jacky Guy

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PubMed ID

22865604

27 November 2017

Raymond A Poot

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27 November 2017

1 October 2012

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27 November 2017

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27 November 2017

2128-2139

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The story of Rett syndrome: from clinic to neurobiology

27 November 2017

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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

21 January 2018

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A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

21 January 2018

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Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

21 January 2018

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Reversal of neurological defects in a mouse model of Rett syndrome

21 January 2018

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Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2.

21 January 2018

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Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state.

21 January 2018

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Mouse models of MeCP2 disorders share gene expression changes in the cerebellum and hypothalamus

21 January 2018

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MeCP2, a key contributor to neurological disease, activates and represses transcription

21 January 2018

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Variation in chromatin structure in two cell types from the same tissue: a short DNA repeat length in cerebral cortex neurons

21 January 2018

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Differentiation of mouse embryonic stem cells into a defined neuronal lineage

21 January 2018

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A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome

21 January 2018

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The major form of MeCP2 has a novel N-terminus generated by alternative splicing

21 January 2018

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Transgenic complementation of MeCP2 deficiency: phenotypic rescue of Mecp2-null mice by isoform-specific transgenes

21 January 2018

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Studies on RNA synthesis in two populations of nuclei from the mammalian cerebral cortex

21 January 2018

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Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth.

21 January 2018

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A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells

21 January 2018

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Isogenic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model

21 January 2018

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Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation

21 January 2018

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Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome

21 January 2018

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Rett syndrome induced pluripotent stem cell-derived neurons reveal novel neurophysiological alterations.

21 January 2018

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Erosion of dosage compensation impacts human iPSC disease modeling

21 January 2018

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X-chromosome inactivation in rett syndrome human induced pluripotent stem cells

21 January 2018

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Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate

21 January 2018

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Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions

21 January 2018

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Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology

21 January 2018

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A role for glia in the progression of Rett's syndrome

21 January 2018

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Cell size regulation, a mechanism that controls cellular RNA accumulation: consequences on regulation of the ubiquitous transcription factors Oct1 and NF-Y and the liver-enriched transcription factor DBP.

21 January 2018

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Nuclear functions in space and time: gene expression in a dynamic, constrained environment

21 January 2018

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Nuclear structure in cancer cells

21 January 2018

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Linker histones are not essential and affect chromatin condensation in vivo

21 January 2018

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MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation.

21 January 2018

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The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression.

21 January 2018

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Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF.

21 January 2018

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Generation of a defined and uniform population of CNS progenitors and neurons from mouse embryonic stem cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/STEM.1180

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27 November 2017

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PubMed ID

22865604