A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome (Q28504458)

Methyl-CpG binding domain protein 2

GOA release 2020-03-11

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GOA release 2020-03-11

B. Hendrich

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Adrian Peter Bird

object named as

A. Bird

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author name string

J. Guy

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24 January 2017

M. Holmes

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24 January 2017

J. E. Martin

A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: report of 35 cases

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24 January 2017

language of work or name

English

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publication date

1 March 2001

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24 January 2017

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24 January 2017

27

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24 January 2017

322–326

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24 January 2017

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24 January 2017

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7 January 2021

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

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7 January 2021

Influence of mutation type and X chromosome inactivation on Rett syndrome phenotypes

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7 January 2021

Rett syndrome and beyond: recurrent spontaneous and familial MECP2 mutations at CpG hotspots

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7 January 2021

MECP2 mutations account for most cases of typical forms of Rett syndrome.

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7 January 2021

Long-read sequence analysis of the MECP2 gene in Rett syndrome patients: correlation of disease severity with mutation type and location.

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7 January 2021

Mutations in the MECP2 gene in a cohort of girls with Rett syndrome

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7 January 2021

Rett syndrome: analysis of MECP2 and clinical characterization of 31 patients.

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7 January 2021

Mutation analysis of the methyl-CpG binding protein 2 gene (MECP2) in patients with Rett syndrome

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7 January 2021

Mutation screening in Rett syndrome patients.

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7 January 2021

Diagnostic testing for Rett syndrome by DHPLC and direct sequencing analysis of the MECP2 gene: identification of several novel mutations and polymorphisms

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7 January 2021

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA

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7 January 2021

DNA methylation specifies chromosomal localization of MeCP2.

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7 January 2021

MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin

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7 January 2021

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

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7 January 2021

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

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7 January 2021

The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse.

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7 January 2021

Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs.

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7 January 2021

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

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7 January 2021

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1

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7 January 2021

A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

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7 January 2021

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

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7 January 2021

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7 January 2021

Methylation-mediated transcriptional silencing in euchromatin by methyl-CpG binding protein MBD1 isoforms

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7 January 2021

Active repression of methylated genes by the chromosomal protein MBD1

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7 January 2021

Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

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7 January 2021

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

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7 January 2021

Functional consequences of Rett syndrome mutations on human MeCP2.

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7 January 2021

DNA recognition by the methyl-CpG binding domain of MeCP2.

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7 January 2021

Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment

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7 January 2021