Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells (Q43805476)

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scientific article published on 15 December 2012

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English	Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells	scientific article published on 15 December 2012

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scholarly article

1 reference

Europe PubMed Central

27 November 2017

Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells (English)

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Europe PubMed Central

27 November 2017

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author name string

Xiaohan Zhai

1

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Europe PubMed Central

27 November 2017

Musen Lin

2

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Europe PubMed Central

27 November 2017

Feng Zhang

3

1 reference

Europe PubMed Central

27 November 2017

Yan Hu

4

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Europe PubMed Central

27 November 2017

Xiaomei Xu

5

1 reference

Europe PubMed Central

27 November 2017

Yubing Li

6

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Europe PubMed Central

27 November 2017

Kexin Liu

7

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Europe PubMed Central

27 November 2017

Xiaochi Ma

8

1 reference

Europe PubMed Central

27 November 2017

Xiaofeng Tian

9

1 reference

Europe PubMed Central

27 November 2017

Jihong Yao

10

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27 November 2017

publication date

15 December 2012

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27 November 2017

Molecular Nutrition and Food Research

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27 November 2017

57

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27 November 2017

2

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27 November 2017

249-259

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27 November 2017

Radical causes of cancer.

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

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Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibility.

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

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NF-E2-related factor 2 activation in PC12 cells: its protective role in manganese-induced damage

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Serum oxidative stress-induced repression of Nrf2 and GSH depletion: a mechanism potentially involved in endothelial dysfunction of young smokers

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AP-1 as a regulator of cell life and death

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NF-kappaB and cancer-identifying targets and mechanisms

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AP-1 subunits: quarrel and harmony among siblings

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Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects

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Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Genistein protects against UVB-induced senescence-like characteristics in human dermal fibroblast by p66Shc down-regulation

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

The novel targets for anti-angiogenesis of genistein on human cancer cells.

1 reference

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21 January 2018

Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Targeting the redox sensitive Nrf2-Keap1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

GM1 expression in caco-2 cells: characterisation of a fundamental passage-dependent transformation of a cell line.

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Differentiation- and polarization-dependent zinc tolerance in Caco-2 cells

1 reference

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21 January 2018

In vitro models for gluten toxicity: relevance for celiac disease pathogenesis and development of novel treatment options

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Bioactive isoflavones in functional foods: the importance of gut microflora on bioavailability

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Advanced separation methods of food anthocyanins, isoflavones and flavanols

1 reference

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21 January 2018

The flavonoid luteolin inhibits Fcγ-dependent respiratory burst in granulocytes, but not skin blistering in a new model of pemphigoid in adult mice.

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggests diet-mediated targeting of cancer stem-like/progenitor cells

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Genistein cooperates with the histone deacetylase inhibitor vorinostat to induce cell death in prostate cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Photoprotective effect of isoflavone genistein on ultraviolet B-induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Comparison of flavonoids and isoflavonoids as antioxidants

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Risk factors for breast cancer: epidemiological evidence from Japanese studies.

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Liquiritigenin, a flavonoid aglycone from licorice, has a choleretic effect and the ability to induce hepatic transporters and phase-II enzymes

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Lipoic acid ameliorates arsenic trioxide-induced HO-1 expression and oxidative stress in THP-1 monocytes and macrophages

1 reference

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21 January 2018

Kaempferol suppresses cisplatin-induced apoptosis via inductions of heme oxygenase-1 and glutamate-cysteine ligase catalytic subunit in HEI-OC1 cell

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

The difference of glutathione antioxidant system in newly weaned and young mice liver and its involvement in isoline-induced hepatotoxicity

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments.

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

H2O2 preconditioning modulates phase II enzymes through p38 MAPK and PI3K/Akt activation.

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200536

21 January 2018

Cigarette smoke particle-phase extract induces HO-1 expression in human tracheal smooth muscle cells: role of the c-Src/NADPH oxidase/MAPK/Nrf2 signaling pathway

1 reference

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Cytoprotective effects of CSTMP, a novel stilbene derivative, against H2O2-induced oxidative stress in human endothelial cells

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Flavonoids protect cerebrovascular endothelial cells through Nrf2 and PI3K from β-amyloid peptide-induced oxidative damage

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21 January 2018

Identifiers

10.1002/MNFR.201200536

1 reference

Europe PubMed Central

27 November 2017

1 reference

Europe PubMed Central

27 November 2017

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