Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death. (Q43283508)

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6 February 2020

title

Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death (English)

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6 February 2020

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8

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Eyal Gottlieb

11

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Daniel A Tennant

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Christian Frezza

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6 February 2020

Darren Roberts

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6 February 2020

author name string

E D MacKenzie

3

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Q D Nguyen

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6 February 2020

L Zheng

5

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M A Selak

6

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D G Watson

9

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E O Aboagye

10

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language of work or name

English

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publication date

31 August 2009

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6 February 2020

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6 February 2020

volume

28

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issue

45

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page(s)

4009-4021

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https://scigraph.springernature.com/pub.10.1038/onc.2009.250

6 February 2020

exact match

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cites work

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

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Genetic instability: the dark side of the hypoxic response.

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Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

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Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

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Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm

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A conserved family of prolyl-4-hydroxylases that modify HIF

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance

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HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

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Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

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The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

31 March 2020

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Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

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Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

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31 March 2020

Identifiers

DOI

10.1038/ONC.2009.250

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19718054%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 February 2020

0 references

1 reference