Novel pathway in Bcr-Abl signal transduction involves Akt-independent, PLC-gamma1-driven activation of mTOR/p70S6-kinase pathway (Q43250891)

17 November 2017

Novel pathway in Bcr-Abl signal transduction involves Akt-independent, PLC-gamma1-driven activation of mTOR/p70S6-kinase pathway (English)

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17 November 2017

B Markova

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17 November 2017

C Albers

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17 November 2017

F Breitenbuecher

3

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17 November 2017

J V Melo

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17 November 2017

T H Brümmendorf

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17 November 2017

F Heidel

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17 November 2017

D Lipka

7

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17 November 2017

J Duyster

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17 November 2017

C Huber

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17 November 2017

T Fischer

10

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17 November 2017

language of work or name

English

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publication date

2 November 2009

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17 November 2017

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29

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5

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17 November 2017

739-751

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https://scigraph.springernature.com/pub.10.1038/onc.2009.374

17 November 2017

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Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development

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BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors

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Combination of imatinib with rapamycin or RAD001 acts synergistically only in Bcr-Abl-positive cells with moderate resistance to imatinib

21 January 2018

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Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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mTOR and cancer therapy

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Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

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Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

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Mammalian target of rapamycin as a therapeutic target in leukemia

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Upstream and downstream of mTOR

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Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain

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ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors

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PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.

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In BCR-ABL-positive cells, STAT-5 tyrosine-phosphorylation integrates signals induced by imatinib mesylate and Ara-C.

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Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration

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Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice

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Role of class II phosphoinositide 3-kinase in cell signalling

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Chronic myeloid leukaemia: stem cell derived but progenitor cell driven

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The Bcr-Abl mutations T315I and Y253H do not confer a growth advantage in the absence of imatinib.

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Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

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Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia

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Intrinsic regulation of the interactions between the SH3 domain of p85 subunit of phosphatidylinositol-3 kinase and the protein network of BCR/ABL oncogenic tyrosine kinase

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Abl: the prototype of oncogenic fusion proteins

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Growing roles for the mTOR pathway

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

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Activated Ca2+/calmodulin-dependent protein kinase IIgamma is a critical regulator of myeloid leukemia cell proliferation

21 January 2018

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Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

21 January 2018

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Studying the pathogenesis of BCR-ABL+ leukemia in mice

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Novel targeted therapies to overcome imatinib mesylate resistance in chronic myeloid leukemia (CML).

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Regulation of phospholipase C gamma isoforms in haematopoietic cells: why one, not the other?

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The mammalian target of rapamycin-p70 ribosomal S6 kinase but not phosphatidylinositol 3-kinase-Akt signaling is responsible for fibroblast growth factor-9-induced cell proliferation.

21 January 2018

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TOR signaling in growth and metabolism

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AKT-independent phosphorylation of TSC2 and activation of mTOR and ribosomal protein S6 kinase signaling by prostaglandin F2alpha

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Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

31 March 2020

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PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.374

Phosphoinositide 3-kinase-dependent regulation of phospholipase Cgamma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.374

Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.374

Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase, insulin growth factor-I, and serum.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.374

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.374

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Dimensions Publication ID

17 November 2017

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