Heat shock proteins in neurodegenerative diseases: pathogenic roles and therapeutic implications (Q43215480)

16 November 2017

Heat shock proteins in neurodegenerative diseases: pathogenic roles and therapeutic implications (English)

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16 November 2017

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1

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16 November 2017

6

Gen Sobue

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16 November 2017

Masahisa Katsuno

2

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16 November 2017

Masahiro Waza

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3

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16 November 2017

Makoto Minamiyama

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4

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16 November 2017

Fumiaki Tanaka

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5

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16 November 2017

1 December 2009

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International Journal of Hyperthermia

16 November 2017

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16 November 2017

25

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16 November 2017

8

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16 November 2017

647-654

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Rethinking ALS: the FUS about TDP-43.

16 November 2017

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Parkinson's disease: from monogenic forms to genetic susceptibility factors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Therapeutics development for triplet repeat expansion diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Nonneural nuclear inclusions of androgen receptor protein in spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Protein surveillance machinery in brains with spinocerebellar ataxia type 3: redistribution and differential recruitment of 26S proteasome subunits and chaperones to neuronal intranuclear inclusions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Sick chaperones, cellular stress, and disease

21 January 2018

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https://api.crossref.org/works/10.3109%2F02656730903315823

Role of heat shock proteins during polyglutamine neurodegeneration: mechanisms and hypothesis

21 January 2018

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https://api.crossref.org/works/10.3109%2F02656730903315823

Polyglutamine protein aggregation and toxicity are linked to the cellular stress response

21 January 2018

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https://api.crossref.org/works/10.3109%2F02656730903315823

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Alterations in the mouse and human proteome caused by Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Decreased expression of Hsp27 and Hsp70 in transformed lymphoblastoid cells from patients with spinocerebellar ataxia type 7.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Decrease of Hsp25 protein expression precedes degeneration of motoneurons in ALS-SOD1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid beta-peptide of amyloid plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Soluble androgen receptor oligomers underlie pathology in a mouse model of spinobulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

21 January 2018

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https://api.crossref.org/works/10.3109%2F02656730903315823

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Modulation of neurodegeneration by molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Celastrol inhibits polyglutamine aggregation and toxicity though induction of the heat shock response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Heat shock transcription factor 1-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Chaperones increase association of tau protein with microtubules

21 January 2018

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https://api.crossref.org/works/10.3109%2F02656730903315823

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Interaction between tau and alpha-synuclein proteins is impaired in the presence of P301L tau mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Induction of multiple heat shock proteins and neuroprotection in a primary culture model of familial amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Pharmacological prevention of Parkinson disease in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Hsp90 inhibitors as novel cancer chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

A receptor for the selective uptake and degradation of proteins by lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Lysosomes, a meeting point of proteins, chaperones, and proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IkappaB kinase (IKK).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Effects of small molecules on chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Targeting toxic proteins for turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

The ubiquitin-proteasome pathway in health and disease of the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Generalized brain and skin proteasome inhibition in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Global changes to the ubiquitin system in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Polyglutamine expansion, protein aggregation, proteasome activity, and neural survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REGgamma as a therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656730903315823

10.3109/02656730903315823

21 January 2018

Identifiers

DOI

1 reference

16 November 2017

1 reference