Hepatitis C virus NS3 inhibitors: current and future perspectives (Q42910831)

11 November 2017

1 reference

26 October 2022

Hepatitis C virus NS3 inhibitors: current and future perspectives (English)

1 reference

viral nonstructural proteins

11 November 2017

1 reference

1 July 2020

1 reference

2 October 2019

1 reference

3 November 2019

1 reference

23 December 2019

1 reference

inferred from abstract

telaprevir

1 reference

based on heuristic

inferred from abstract

boceprevir

1 reference

based on heuristic

inferred from abstract

1

Kazi Abdus Salam

1 reference

11 November 2017

2

Nobuyoshi Akimitsu

1 reference

PMCID

3825274

11 November 2017

language of work or name

English

0 references

publication date

27 October 2013

10 references

BioMed Research International

11 November 2017

23 March 2019

21 March 2019

2 October 2019

3 November 2019

23 December 2019

1 July 2020

22 October 2022

25 October 2022

26 October 2022

10 references

11 November 2017

23 March 2019

21 March 2019

2 October 2019

3 November 2019

23 December 2019

1 July 2020

22 October 2022

25 October 2022

26 October 2022

2013

1 reference

11 November 2017

467869

1 reference

Creative Commons Attribution 3.0 Unported

11 November 2017

9 references

23 March 2019

21 March 2019

2 October 2019

3 November 2019

23 December 2019

1 July 2020

22 October 2022

25 October 2022

on focus list of Wikimedia project

26 October 2022

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

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Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment

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Studies on the anti-hepatitis C virus activity of newly synthesized tropolone derivatives: identification of NS3 helicase inhibitors that specifically inhibit subgenomic HCV replication

27 May 2018

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Synthesis of new acridone derivatives, inhibitors of NS3 helicase, which efficiently and specifically inhibit subgenomic HCV replication

27 May 2018

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Mechanism and Specificity of a Symmetrical Benzimidazolephenylcarboxamide Helicase Inhibitor

27 May 2018

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Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism

27 May 2018

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Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virus helicase

27 May 2018

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Diagnosis, management, and treatment of hepatitis C: an update

27 May 2018

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Peginterferon alfa-2a and ribavirin in Latino and non-Latino whites with hepatitis C.

27 May 2018

1 reference

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Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors

27 May 2018

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Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly

27 May 2018

1 reference

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Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein

27 May 2018

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Peginterferon alfa-2a and ribavirin for 16 or 24 weeks in HCV genotype 2 or 3.

27 May 2018

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Replication of hepatitis C virus

27 May 2018

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An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: Synthesis and in vitro screening of 4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-β-d-ribofuranoside

27 May 2018

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Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase

27 May 2018

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Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein

27 May 2018

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The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein/F-protein, the double-frameshift protein, and others

27 May 2018

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Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA.

27 May 2018

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Peginterferon alfa-2b and ribavirin for the treatment of chronic hepatitis C in blacks and non-Hispanic whites

27 May 2018

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Effect of interaction between hepatitis C virus NS5A and NS5B on hepatitis C virus RNA replication with the hepatitis C virus replicon

27 May 2018

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The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently

27 May 2018

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Nonstructural Protein Precursor NS4A/B from Hepatitis C Virus Alters Function and Ultrastructure of Host Secretory Apparatus

27 May 2018

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The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives

27 May 2018

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The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine

27 May 2018

2 references

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27 May 2018

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Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection

21 January 2018

1 reference

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Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex

27 May 2018

1 reference

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The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825274

Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunit

27 May 2018

1 reference

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Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo

27 May 2018

1 reference

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The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3)

27 May 2018

1 reference

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Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus

27 May 2018

1 reference

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Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins

27 May 2018

1 reference

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Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A

27 May 2018

1 reference

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Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

27 May 2018

1 reference

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Structure and organization of the hepatitis C virus genome isolated from human carriers

27 May 2018

1 reference

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Transfusion-Associated Hepatitis Not Due to Viral Hepatitis Type A or B

27 May 2018

1 reference

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A phase 2a trial of 12-week interferon-free therapy with two direct-acting antivirals (ABT-450/r, ABT-072) and ribavirin in IL28B C/C patients with chronic hepatitis C genotype 1.

27 May 2018

1 reference

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Guidelines for the Management of Hepatitis C Virus Infection: First edition, May 2012, The Japan Society of Hepatology

16 August 2018

1 reference

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Hepatitis C treatment highlights from the 2011 American Association for the Study of Liver Disease meeting

16 August 2018

1 reference

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Inhibition of hepatitis C virus NS3 helicase by manoalide.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825274

Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders

16 August 2018

1 reference

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Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection

16 August 2018

1 reference

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Introduction: a smouldering public-health crisis

16 August 2018

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Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825274

Inhibition of subgenomic hepatitis C virus RNA replication by acridone derivatives: identification of an NS3 helicase inhibitor

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825274

New acridone-4-carboxylic acid derivatives as potential inhibitors of hepatitis C virus infection.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825274

Viral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI).

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825274

Tropolone and its derivatives as inhibitors of the helicase activity of hepatitis C virus nucleotide triphosphatase/helicase

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825274

Searching for a new anti-HCV therapy: synthesis and properties of tropolone derivatives

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825274

Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825274

The pathway of HCV IRES-mediated translation initiation

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825274

Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825274

Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825274

Structural biology of hepatitis C virus

16 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1155%2F2013%2F467869

Progress toward development of a hepatitis C vaccine with broad shoulders

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24282816

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1155/2013/467869

1 reference

11 November 2017

1 reference

11 November 2017

1 reference

PMCID

3825274