Mechanism and Specificity of a Symmetrical Benzimidazolephenylcarboxamide Helicase Inhibitor (Q27491015)

1

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Yoji D High

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Tse-I Lin

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Frederik Pauwels

Helicase inhibitors as specifically targeted antiviral therapy for hepatitis C

4

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language of work or name

English

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publication date

9 March 2010

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published in

Biochemistry

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volume

49

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issue

9

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page(s)

1822-32

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cites work

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The NS4A Protein of Hepatitis C Virus Promotes RNA-Coupled ATP Hydrolysis by the NS3 Helicase

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NS3 Helicase from the Hepatitis C Virus Can Function as a Monomer or Oligomer Depending on Enzyme and Substrate Concentrations

20 March 2017

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Ring Expanded Nucleoside Analogues Inhibit RNA Helicase and Intracellular Human Immunodeficiency Virus Type 1 Replication

20 March 2017

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Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population Level

20 March 2017

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NS3 Peptide, a Novel Potent Hepatitis C Virus NS3 Helicase Inhibitor: Its Mechanism of Action and Antiviral Activity in the Replicon System

20 March 2017

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Structure and biochemical analysis of Kokobera virus helicase

20 March 2017

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Crystal Structure of the NS3 Protease-Helicase from Dengue Virus

20 March 2017

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Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors

20 March 2017

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Role of Divalent Metal Cations in ATP Hydrolysis Catalyzed by the Hepatitis C Virus NS3 Helicase: Magnesium Provides a Bridge for ATP to Fuel Unwinding

20 March 2017

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Structure of the Dengue Virus Helicase/Nucleoside Triphosphatase Catalytic Domain at a Resolution of 2.4 A

20 March 2017

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Hepatitis C Virus NS3 ATPases/Helicases from Different Genotypes Exhibit Variations in Enzymatic Properties

20 March 2017

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Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase

20 March 2017

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Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding

20 March 2017

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Complete replication of hepatitis C virus in cell culture

20 March 2017

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Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection

20 March 2017

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

20 March 2017

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Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function

20 March 2017

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Genetic diversity and evolution of hepatitis C virus--15 years on

20 March 2017

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An improved assay for nanomole amounts of inorganic phosphate

7 April 2017

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Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virus helicase

7 April 2017

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Amidinoanthracyclines - a new group of potential anti-hepatitis C virus compounds

29 September 2017

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The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target

29 September 2017

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Understanding helicases as a means of virus control.

29 September 2017

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Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus

29 September 2017

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Viral and cellular RNA helicases as antiviral targets

29 September 2017

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Enhanced nucleic acid binding to ATP-bound hepatitis C virus NS3 helicase at low pH activates RNA unwinding

29 September 2017

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Sensitivity of NS3 serine proteases from hepatitis C virus genotypes 2 and 3 to the inhibitor BILN 2061.

29 September 2017

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The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently

29 September 2017

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Two novel conserved motifs in the hepatitis C virus NS3 protein critical for helicase action

29 September 2017

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Biological evaluation of hepatitis C virus helicase inhibitors

29 September 2017

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A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity

29 September 2017

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A steady-state and pre-steady-state kinetic analysis of the NTPase activity associated with the hepatitis C virus NS3 helicase domain

29 September 2017

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Inhibition of subgenomic hepatitis C virus RNA replication by acridone derivatives: identification of an NS3 helicase inhibitor

2 June 2018

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The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate

27 November 2018

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Kinetic effects due to nonspecific substrate-inhibitor interactions in enzymatic reactions

27 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20108979