Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation (Q42812372)

7 November 2017

title

Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation (English)

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7 November 2017

Lin R

1

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7 November 2017

Cerione RA

series ordinal

2

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7 November 2017

Manor D

series ordinal

3

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7 November 2017

language of work or name

English

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publication date

1 August 1999

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Journal of Biological Chemistry

7 November 2017

published in

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7 November 2017

volume

274

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7 November 2017

issue

33

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7 November 2017

page(s)

23633-23641

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Isolation of a new human oncogene from a diffuse B-cell lymphoma.

7 November 2017

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Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation

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Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

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CDC42 and FGD1 cause distinct signaling and transforming activities

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A novel Cdc42Hs mutant induces cellular transformation

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Use of a fluorescence spectroscopic readout to characterize the interactions of Cdc42Hs with its target/effector, mPAK-3.

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Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

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Transphosphorylation and G protein activation

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A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

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Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

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The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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Rho GTPases and the actin cytoskeleton

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Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

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Activation of Rac and Cdc42 by integrins mediates cell spreading

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A role for Cdc42 in macrophage chemotaxis

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Rho proteins play a critical role in cell migration during the early phase of mucosal restitution

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Gelsolin is a downstream effector of rac for fibroblast motility

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The GTPase Rho has a critical regulatory role in thymus development

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The Rho family G proteins play a critical role in muscle differentiation

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Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity

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The role of RhoA in tissue polarity and Frizzled signalling

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Cell shape determination: a pivotal role for Rho.

21 January 2018

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DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila

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The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation

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Direct involvement of the small GTP-binding protein Rho in lbc oncogene function

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

21 January 2018

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Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium.

21 January 2018

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Characteristics of an assay for Rous sarcoma virus and Rous sarcoma cells in tissue culture

21 January 2018

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Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling

21 January 2018

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Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

21 January 2018

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Guanine nucleotide exchange factors for the Rho GTPases: a role in human disease?

21 January 2018

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The small GTPases Cdc42Hs, Rac1 and RhoG delineate Raf-independent pathways that cooperate to transform NIH3T3 cells

21 January 2018

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Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras

21 January 2018

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Transformation mediated by RhoA requires activity of ROCK kinases

21 January 2018

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A Rac1 effector site controlling mitogenesis through superoxide production

21 January 2018

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Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.33.23633

1 reference

7 November 2017

1 reference