PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells (Q42811887)

7 November 2017

PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells (English)

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7 November 2017

Yong Choi

1

1 reference

7 November 2017

Jie Zhang

2

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7 November 2017

Cristina Murga

3

1 reference

7 November 2017

Hong Yu

4

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7 November 2017

Erich Koller

5

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7 November 2017

Brett P Monia

6

1 reference

7 November 2017

J Silvio Gutkind

7

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7 November 2017

Weiqun Li

8

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7 November 2017

language of work or name

English

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publication date

1 August 2002

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7 November 2017

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7 November 2017

21

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7 November 2017

34

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7 November 2017

5289-5300

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205650

7 November 2017

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

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RAFTK/PYK2-dependent and -independent apoptosis in multiple myeloma cells.

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A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

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Update on the treatment of multiple myeloma

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Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP

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Protein kinase C-delta is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformation

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SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-alpha expression

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The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

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Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells

21 January 2018

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Signalling through the lipid products of phosphoinositide-3-OH kinase

21 January 2018

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The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

21 January 2018

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High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

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Mechanism of activation of protein kinase B by insulin and IGF-1

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1205650

1 reference

Dimensions Publication ID

7 November 2017

0 references

1 reference