A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development (Q42709815)

5 November 2017

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development (English)

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5 November 2017

Ryan E Morgan

1

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5 November 2017

Carlo J van Staden

2

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5 November 2017

Yuan Chen

3

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5 November 2017

Natarajan Kalyanaraman

4

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5 November 2017

Jackson Kalanzi

5

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5 November 2017

Robert T Dunn

6

1 reference

5 November 2017

Cynthia A Afshari

7

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5 November 2017

Hisham K Hamadeh

8

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5 November 2017

16 August 2013

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5 November 2017

Toxicological Sciences

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5 November 2017

136

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5 November 2017

1

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5 November 2017

216-241

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The primary role of hepatic metabolism in idiosyncratic drug-induced liver injury

5 November 2017

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

The Conduct of In Vitro and In Vivo Drug-Drug Interaction Studies: A PhRMA Perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Current challenges and controversies in drug-induced liver injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Drug-induced liver injury: past, present and future.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Estradiol 3-glucuronide is transported by the multidrug resistance-associated protein 2 but does not activate the allosteric site bound by estradiol 17-glucuronide

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Application of genomics for identification of systemic toxicity triggers associated with VEGF-R inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Characterization of 5(6)-carboxy-2,'7'-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Cholestasis and the role of basolateral efflux pumps

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

The bile salt export pump (BSEP) in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Limited modulation of the transport activity of the human multidrug resistance proteins MRP1, MRP2 and MRP3 by nicotine glucuronide metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Species-specific and age-dependent bile acid composition: aspects on CYP8B and CYP4A subfamilies in bile acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

The apical conjugate efflux pump ABCC2 (MRP2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Concordance of the toxicity of pharmaceuticals in humans and in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Mitochondrially-mediated toxicity of bile acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Mitochondrially mediated synergistic cell killing by bile acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Role of the bile salt export pump, BSEP, in acquired forms of cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

The bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Drug-induced liver injury: a summary of recent advances.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Bile salt transporters: molecular characterization, function, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Mechanisms of drug-induced liver injury: from bedside to bench

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

Nuclear receptors as drug targets in cholestasis and drug-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT176

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFT176

1 reference

5 November 2017

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