A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro. (Q42702995)

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scientific article published on 26 January 2015

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English	A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro.	scientific article published on 26 January 2015

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scholarly article

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26 February 2020

A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro (English)

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26 February 2020

Alzheimer's disease

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Dual specificity tyrosine phosphorylation regulated kinase 1A

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GOA release 2020-03-11

amyloid-beta formation

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GOA release 2020-03-11

phosphorylation

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based on heuristic

inferred from title

Bertrand Leblond

5

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26 February 2020

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26 February 2020

author name string

Séverine Coutadeur

1

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26 February 2020

Hélène Benyamine

2

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26 February 2020

Laurence Delalonde

3

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26 February 2020

Catherine de Oliveira

4

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26 February 2020

Alicia Foucourt

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26 February 2020

Anne-Sophie Casagrande

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26 February 2020

Thierry Taverne

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26 February 2020

Angélique Girard

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26 February 2020

Matthew P Pando

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26 February 2020

Laurent Désiré

12

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26 January 2015

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26 February 2020

Journal of Neurochemistry

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440-451

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26 February 2020

3

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26 February 2020

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

DYRK1A: a potential drug target for multiple Down syndrome neuropathologies

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Neuropathological stageing of Alzheimer-related changes

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Mirk/Dyrk1B in cancer

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

β-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sites

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Trans-synaptic spread of tau pathology in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Tau protein kinases: involvement in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Function and regulation of Dyrk1A: towards understanding Down syndrome

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Tau is essential to beta -amyloid-induced neurotoxicity

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Tau as a biomarker of neurodegenerative diseases.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Biochemistry of Tau in Alzheimer's disease and related neurological disorders.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

DYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

The role of DYRK1A in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13018

21 January 2018

Identifiers

10.1111/JNC.13018

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26 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25556849%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

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