DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease (Q40074162)

17 September 2017

DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease (English)

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Dual specificity tyrosine phosphorylation regulated kinase 1A

17 September 2017

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microtubule associated protein tau

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tau protein binding

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Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a

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Microtubule-associated protein tau

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Soo-Ryoon Ryoo

1

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17 September 2017

Hey Kyeong Jeong

2

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17 September 2017

Chinzorig Radnaabazar

3

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17 September 2017

Jin-Ju Yoo

4

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17 September 2017

Hyun-Jeong Cho

5

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17 September 2017

Hye-Won Lee

6

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17 September 2017

In-Sook Kim

7

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17 September 2017

Young-Hee Cheon

8

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17 September 2017

Young Soo Ahn

9

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17 September 2017

Sul-Hee Chung

10

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17 September 2017

Woo-Joo Song

11

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17 September 2017

language of work or name

English

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publication date

28 September 2007

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Journal of Biological Chemistry

17 September 2017

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17 September 2017

282

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17 September 2017

34850-34857

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17 September 2017

48

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Down syndrome phenotypes: the consequences of chromosomal imbalance

17 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M707358200

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M707358200

Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M707358200

The molecular pathology of Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M707358200

Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M707358200

Tau phosphorylation in neuronal cell function and dysfunction

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M707358200

Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M707358200

A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707358200

Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707358200

Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region"

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M707358200

Expression of the mnb (dyrk) protein in adult and embryonic mouse tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707358200

Expression patterns and subcellular localization of the Down syndrome candidate protein MNB/DYRK1A suggest a role in late neuronal differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707358200

Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707358200

Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707358200

Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707358200

The MNB/DYRK1A protein kinase: genetic and biochemical properties

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M707358200

Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M707358200

DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707358200

Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707358200

Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707358200

Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707358200

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707358200

Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M707358200

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M707358200

Hyperphosphorylation of tau induces local polyproline II helix.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707358200

Pseudo-phosphorylation of tau at Ser202 and Thr205 affects tau filament formation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M707358200

Site-specific pseudophosphorylation modulates the rate of tau filament dissociation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M707358200

Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707358200

Sequential phosphorylation of tau protein by cAMP-dependent protein kinase and SAPK4/p38delta or JNK2 in the presence of heparin generates the AT100 epitope.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707358200

Untangling memory deficits.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M707358200

Tau suppression in a neurodegenerative mouse model improves memory function

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M707358200

Deciphering the molecular basis of memory failure in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M707358200

Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707358200

Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707358200

21 January 2018

Identifiers

DOI

10.1074/JBC.M707358200

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17 September 2017

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