Multiplexed genetic engineering of human hematopoietic stem and progenitor cells using CRISPR/Cas9 and AAV6. (Q42631262)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28956530%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

title

Multiplexed genetic engineering of human hematopoietic stem and progenitor cells using CRISPR/Cas9 and AAV6 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28956530%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference

0 references

1

1 reference

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31 March 2020

Andreas Reinisch

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28956530%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Matthew H Porteus

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28956530%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

author name string

Daniel P Dever

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28956530%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

David Cruz Hernandez

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28956530%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Ravindra Majeti

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28956530%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

language of work or name

English

0 references

publication date

28 September 2017

1 reference

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31 March 2020

1 reference

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31 March 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28956530%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

31 March 2020

1 reference

CRISPR-Mediated Integration of Large Gene Cassettes Using AAV Donor Vectors

1 reference

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Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection.

27 May 2018

1 reference

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Targeted Repair of CYBB in X-CGD iPSCs Requires Retention of Intronic Sequences for Expression and Functional Correction

27 May 2018

1 reference

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CRISPR-Cas9 gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease.

27 May 2018

1 reference

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CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells

27 May 2018

1 reference

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A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells

27 May 2018

1 reference

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Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells

27 May 2018

1 reference

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CRISPR/Cas9-Mediated Correction of the Sickle Mutation in Human CD34+ cells

27 May 2018

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A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells

27 May 2018

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Targeted gene editing restores regulated CD40L function in X-linked hyper-IgM syndrome

27 May 2018

1 reference

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Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation

27 May 2018

1 reference

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Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors.

27 May 2018

1 reference

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Gene therapy returns to centre stage

27 May 2018

1 reference

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Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Multiplex Genome-Edited T-cell Manufacturing Platform for "Off-the-Shelf" Adoptive T-cell Immunotherapies

27 May 2018

1 reference

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Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Efficient genome editing in hematopoietic stem cells with helper-dependent Ad5/35 vectors expressing site-specific endonucleases under microRNA regulation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Enforced fucosylation of cord blood hematopoietic cells accelerates neutrophil and platelet engraftment after transplantation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

CRISPR-Cas9 knockin mice for genome editing and cancer modeling

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Targeted genome editing in human repopulating haematopoietic stem cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

27 May 2018

1 reference

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Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV

27 May 2018

1 reference

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Nuclease-mediated gene editing by homologous recombination of the human globin locus

27 May 2018

1 reference

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Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation

27 May 2018

1 reference

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27 May 2018

1 reference

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Multiplex genome engineering using CRISPR/Cas systems

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Cord-blood engraftment with ex vivo mesenchymal-cell coculture

27 May 2018

1 reference

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Universal real-time PCR for the detection and quantification of adeno-associated virus serotype 2-derived inverted terminal repeat sequences

27 May 2018

1 reference

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Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Hematopoiesis: a human perspective

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

AAV-mediated gene targeting methods for human cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Hematopoietic stem cell: self-renewal versus differentiation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Gene therapy: therapeutic gene causing lymphoma

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Adeno-associated virus vectors integrate at chromosome breakage sites

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Multiplexed Targeted Genome Engineering Using a Universal Nuclease-Assisted Vector Integration System

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5656432

Safety of retroviral gene marking with a truncated NGF receptor

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28956530

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.7554/ELIFE.27873

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28956530%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28956530%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference