TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals (Q42511575)

1 November 2017

TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals (English)

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7

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B Neve

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François Pattou

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F Pattou

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O Le Bacquer

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J Kerr-Conte

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S Gargani

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N Delalleau

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M Huyvaert

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V Gmyr

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language of work or name

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22 August 2012

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55

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2677-2681

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https://scigraph.springernature.com/pub.10.1007/s00125-012-2660-8

1 November 2017

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New type 2 diabetes risk genes provide new insights in insulin secretion mechanisms

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TCF7L2 splice variants have distinct effects on beta-cell turnover and function

21 January 2018

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Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

21 January 2018

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Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes

21 January 2018

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Primary graft function, metabolic control, and graft survival after islet transplantation

21 January 2018

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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

21 January 2018

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Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice.

21 January 2018

1 reference

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Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors

21 January 2018

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Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-012-2660-8

Neonatal growth and regeneration of beta-cells are regulated by the Wnt/beta-catenin signaling in normal and diabetic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2660-8

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2660-8

Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea

21 January 2018

1 reference

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10.1007/S00125-012-2660-8

21 January 2018

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DOI

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1 November 2017

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