Acquired resistance to the anticancer drug paclitaxel is associated with induction of cytochrome P450 2C8. (Q42496419)

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29 January 2020

title

Acquired resistance to the anticancer drug paclitaxel is associated with induction of cytochrome P450 2C8 (English)

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29 January 2020

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1

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Ramiro Jover

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29 January 2020

José Agundez

7

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author name string

Rosa M Pizarro

2

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29 January 2020

Carmen Martínez

3

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29 January 2020

Yolanda Gutierrez-Martín

4

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Gabriela Pérez

5

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publication date

1 June 2006

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29 January 2020

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volume

7

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issue

4

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page(s)

575-585

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Enzyme-catalyzed activation of anticancer prodrugs

29 January 2020

cites work

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Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide

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Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.

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Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma

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Induction of cytochrome P450 3A4 by docetaxel in peripheral mononuclear cells and its expression in lung cancer

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Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes

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The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

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Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy

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Aminopyrine N-demethylase activity in human liver microsomes

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Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively

21 January 2018

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Cyclosporin A does not reverse clinical resistance to paclitaxel in patients with relapsed non-Hodgkin's lymphoma

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GBP1 overexpression is associated with a paclitaxel resistance phenotype

21 January 2018

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Microtubule-associated protein tau: a marker of paclitaxel sensitivity in breast cancer

21 January 2018

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The penetration of anticancer drugs through tumor tissue as a function of cellular adhesion and packing density of tumor cells

21 January 2018

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Decreased expression of cytochrome P450 protein in non-malignant colonic tissue of patients with colonic adenoma

21 January 2018

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CYP2C and IL-6 expression in breast cancer

21 January 2018

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A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes

21 January 2018

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The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects.

21 January 2018

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Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms

21 January 2018

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21 January 2018

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Semi-automatic quantitative RT-PCR to measure CYP induction by drugs in human hepatocytes

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/14622416.7.4.575

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29 January 2020

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