paclitaxel (Q423762)

Gene Ontology release 2020-05-02

3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase activity

1 reference

http://geneontology.org/external2go/rhea2go

1 February 2021

1 reference

Paclitaxel (English)

17 November 2015

1 reference

English Wikipedia

chemical probe

1 reference

https://www.chemicalprobes.org/taxol

chemical structure

Taxol.svg
430 × 291; 32 KB

criterion used

structure representation with unlabelled terminal carbon atoms

1 reference

structure representation with labelled terminal carbon atoms

German Wikipedia

Struktur Paclitaxel.svg
670 × 400; 29 KB

criterion used

0 references

image of molecular model or crystal lattice model

Paclitaxel JMolBiol 2001 1045.jpg
666 × 738; 33 KB

0 references

PACLitaxel

Institute for Safe Medication Practices

1 reference

https://www.ismp.org/recommendations/tall-man-letters-list

(2R,3R)-3-(Benzoylamino)-2-hydroxy-3-phenylpropionic acid 1,7beta-dihydroxy-2alpha-(benzoyloxy)-4,10beta-diacetoxy-9-oxo-5beta,20-epoxytaxa-11-ene-13alpha-yl ester

2 September 2022

stereoisomer of

1 reference

1 reference

1 reference

C₄₇H₅₁NO₁₄

1 reference

paclitaxel (English)

18 November 2016

CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

1 reference

paclitaxel (English)

18 November 2016

CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

1 reference

European Medicines Agency product number

paclitaxel (English)

18 November 2016

1 reference

EMEA/H/C/000778

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000778/human_med_000620.jsp

European Medicines Agency product number

22 March 2017

Paxene

1 reference

EMEA/H/C/000216

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000216/human_med_000972.jsp

World Health Organisation international non-proprietary name

22 March 2017

paclitaxel polyglutamate

0 references

paclitaxel (English)

1 reference

A Brief Survey of Taxus Alkaloids and Other Taxane Derivatives

Paclitaxel (English)

19 January 2016

34 references

Biosynthesis of Taxol

Concentrations of taxol and related taxanes in the needles of differentTaxus cultivars

Purification and characterization of taxa-4(5),11(12)-diene synthase from Pacific yew (Taxus brevifolia) that catalyzes the first committed step of taxol biosynthesis

Heterologous expression and characterization of a "Pseudomature" form of taxadiene synthase involved in paclitaxel (Taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction

Embryo culture and taxane production inTaxus spp

Free taxanes and the release of bound compounds having taxane antibody reactivity by xylanase in female, haploid-derived cell suspension cultures ofTaxus brevifolia

Determination of taxol in Taxus species grown in Hungary by high-performance liquid chromatography-diode array detection effect of vegetative period

Taxol content in the seeds of Taxus SPP

Taxol partitioning in two-phase plant cell cultures of Taxus brevifolia

Taxol formation in yew — Taxus

Supercritical extraction of taxol from the bark of Taxus brevifolia

Rapid screening for taxanes by tandem mass spectrometry

High-performance liquid chromatographic assay of taxol

Mechanism of taxadiene synthase, a diterpene cyclase that catalyzes the first step of taxol biosynthesis in Pacific yew

Biosynthesis of taxoids. Mode of formation of the taxol side chain

New taxanes from Taxus brevifolia

Taxus spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia: analysis and isolation

Taxol content in bark, wood, root, leaf, twig, and seedling from several Taxus species

Effects of genetic, epigenetic, and environmental factors on taxol content in Taxus brevifolia and related species

Taxol and Cephalomannine Concentrations in the Foliage and Bark of Shade-Grown and Sun-Exposed Taxus brevifolia Trees

Determination of Taxanes in Taxus brevifolia Extracts by Tandem Mass Spectrometry and High-Performance Liquid Chromatography

Brevitaxin, a new diterpenolignan from the bark of Taxus brevifolia

Taxol and taxane formation in plant cell culture

Neutral and basic taxoid contents in the needles of Taxus species

Taxol Biosynthesis: An Update

Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yew

A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis

HPLC Separation of Taxol and Cephalomannine

Methodology for the Identification and Purification of Taxol and Cephalomannine from Taxus Callus Cultures

EFFICIENT EXTRACTION OF PACLITAXEL AND RELATED TAXOIDS FROM LEAF TISSUE OF TAXUS USING A POTABLE SOLVENT SYSTEM

Biosynthetic studies on taxol

Biosynthetic Studies on Taxol

Biosynthesis of Taxol

Taxus canadensis

17 references

Determination of taxane concentrations in Taxus canadensis clippings using high performance liquid chromatographic analysis with an internal standard

Analysis of taxol and related taxanes fromtaxus canadensis using liquid chromatography combined with mass spectrometry or tandem mass spectrometry

Taxol production and taxadiene synthase activity in Taxus canadensis cell suspension cultures

Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesis

Preparative separation of taxol in normal- and reversed-phase operations

Two new taxanes from Taxus canadensis

Biosynthetic building blocks of taxanes

Challenges in the isolation of taxanes from Taxus canadensis by fast pyrolysis

Oligosaccharides potentiate methyl jasmonate-induced production of paclitaxel in Taxus canadensis

Rapid screening for taxanes by tandem mass spectrometry

Taxus spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia: analysis and isolation

Isolation of 9-Dihydro-13-acetylbaccatin III from Taxus canadensis

Isolation of labeled 9-dihydrobaccatin III and related taxoids from cell cultures of taxuscell cultures of taxus canadensis elicited with m

Neutral and basic taxoid contents in the needles of Taxus species

Yew (Taxus) Species - Chemical And Morphological Variations

Seasonal Changes in the Concentration of Major Taxanes in the Biomass of Wild Canada Yew (Taxus canadensis. Marsh.)

Corylus avellana

1 reference

Taxanes from Shells and Leaves of Corylus avellana

Pestalotiopsis guepinii

1 reference

Pestalotiopsis guepinii, a Taxol-producing Endophyte of the Wollemi Pine, Wollemia nobilis

Pestalotiopsis microspora

4 references

Stimulation of taxol production in liquid cultures of Pestalotiopsis microspora

Evidence for paclitaxel from three new endophytic fungi of Himalayan yew of Nepal

Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana

Endophytic taxol-producing fungi from bald cypress, Taxodium distichum

Afrocarpus gracilior

1 reference

The occurrence of the anti-cancer diterpene taxol in Podocarpus gracilior Pilger (Podocarpaceae)

Seimatoantlerium tequiensis

1 reference

Seimatoantlerium tepuiense gen. nov., a unique epiphytic fungus producing taxol from the Venezuelan Guyana

Taxomyces andreanae

2 references

The search for a taxol-producing microorganism among the endophytic fungi of the Pacific yew, Taxus brevifolia

Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew.

Taxus floridana

3 references

Rapid screening for taxanes by tandem mass spectrometry

Neutral and basic taxoid contents in the needles of Taxus species

A Large Scale Process for Paclitaxel and other Taxanes from the Needles of Taxus x Media Hicksii and Taxus Floridana Using Reverse Phase Column Chromatography

Taxus sumatrana

4 references

Novel taxane diterpenes from Taxus sumatrana with the first C-21 taxane ester

Taxol and its related taxoids from the needles of Taxus sumatrana.

Chemical Study of Indonesian Medicinal Plants

Novel Taxane Diterpenes from Taxus sumatrana with the First C-21 Taxane Ester

Torreya californica

1 reference

Trichothecium

1 reference

Evidence for paclitaxel from three new endophytic fungi of Himalayan yew of Nepal

Nectria

1 reference

Taxol from Tubercularia sp. strain TF5, an endophytic fungus of Taxus mairei

Tubercularia

1 reference

Taxol from Tubercularia sp. strain TF5, an endophytic fungus of Taxus mairei

Phyllosticta tabernaemontanae

1 reference

Isolation and identification of an anticancer drug, taxol from Phyllosticta tabernaemontanae, a leaf spot fungus of an angiosperm, Wrightia tinctoria

Homo sapiens

1 reference

A community-driven global reconstruction of human metabolism.

Taxus

7 references

Analysis of taxol and related diterpenoids from cell cultures by liquid chromatography-electrospray mass spectrometry

High-performance liquid chromatography and micellar electrokinetic chromatography of taxol and related taxanes from bark and needle extracts of Taxus species

A simplified method for the determination of taxanes in yew needles by reversed-phase (C18) high pressure liquid chromatography

PREPARATIVE CHROMATOGRAPHIC SEPARATION OF TAXOL FROM YEW TREES

Adsorption characteristics and separation of taxol from yew tree by NP-HPLC

Taxanes from Taxus x media

Paclitaxel Analogues fromTaxus×mediacv. Hicksii

Taxus baccata

41 references

Methodology for the Identification and Purification of Taxol and Cephalomannine from Taxus Callus Cultures

Immunoenzymatic methods applied to the search for bioactive taxoids from Taxus baccata

Taxol on the surface of leaves and inside the needles of three species and two varieties of Taxus

Sample preparation for taxol and cephalomannine determination in various organs of Taxus sp

Analysis of taxol, 10-deacetylbaccatin III and related compounds in Taxus baccata

Taxol production in suspension cultures of Taxus baccata

Production of taxanes by Taxus baccata plant cells

Taxol content of Irish yews

Seasonal changes in the concentrations of four taxoids in Taxus baccata L. during the autumn-spring period

Seasonal variations in the content of taxanes in the bark of Taxus baccata L.

INVESTIGATIONS ON PREPARATIVE THIN-LAYER CHROMATOGRAPHIC SEPARATION OF TAXOIDS FROM TAXUS BACCATA L.

Concentrations of taxol and related taxanes in the needles of differentTaxus cultivars

Screening for pharmaceutically important taxoids in Taxus baccata var. Aurea corr. with CC/SPE/HPLC-PDA procedure

Yew (Taxus) Species - Chemical And Morphological Variations

Neutral and basic taxoid contents in the needles of Taxus species

Seasonal variation of neutral and basic taxoid contents in shoots of European Yew (Taxus baccata)

Taxol content in the bark of Himalayan Yew in relation to tree age and sex.

Taxanes in Taxus baccata pollen: cardiotoxicity and/or allergenicity?

Taxus spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia: analysis and isolation

Taxol content in bark, wood, root, leaf, twig, and seedling from several Taxus species

Effects of genetic, epigenetic, and environmental factors on taxol content in Taxus brevifolia and related species

Relationships between the structures of taxol and baccatine III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum amoebal microtubules

New bioactive taxoids from cell cultures of Taxus baccata

Taxanes from Taxus baccata

A yew in Israel, new taxane derivatives

Taxol content in the seeds of Taxus SPP

Taxol Content in the Storage Samples of the Needles of Himalayan Taxus baccata and their Extracts

Application of supercritical fluid extraction and supercritical fluid chromatography to the production of taxanes as anti-cancer drugs

Production of Taxol® and baccatin III by a selected Taxus baccata callus line and its derived cell suspension culture

Antimicrobial activity of the heartwood of Taxus baccata

Method of isolating taxol from Taxus baccata

High-Speed Countercurrent Chromatography Separation of Taxol and Related Diterpenoids fromTaxus Baccata

Rapid screening for taxanes by tandem mass spectrometry

Determination of paclitaxel and related diterpenoids in plant extracts by high-performance liquid chromatography with UV detection in high-performance liquid chromatography–mass spectrometry

Taxol production in bioreactors: Kinetics of biomass accumulation, nutrient uptake, and taxol production by cell suspensions of Taxus baccata

Induction of geranylgeranyl diphosphate synthase activity and taxane accumulation in Taxus baccata cell cultures after elicitation by methyl jasmonate

Geranylgeranyl diphosphate synthase activity and taxane production in Taxus baccata cells

Taxol transport in Taxus baccata cell suspension cultures

A Yew in Israel, New Taxane Derivatives

Production of Taxanes in a Bioreactor by Taxus baccata Cells

Plocamium cornutum

1 reference

Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay

Paraconiothyrium

1 reference

Interactions between Co-Habitating fungi Elicit Synthesis of Taxol from an Endophytic Fungus in Host Taxus Plants.

Aspergillus versicolor

2 references

HPLC-DAD-Directed Isolation of Linearly Fused Prenylated Indole Alkaloids from a Soil-Derived Aspergillus versicolor

Proversilins A-E, Drimane-Type Sesquiterpenoids from the Endophytic Aspergillus versicolor

Cúrcuma longa

1 reference

Terpecurcumins A-I from the rhizomes of Curcuma longa: absolute configuration and cytotoxic activity

Aspergillus ochraceopetaliformis

2 references

Antiviral Merosesquiterpenoids Produced by the Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702.

Ochracenes A-I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformis

Cedrus deodara

1 reference

Tubulin Inhibitors from an Endophytic Fungus Isolated from Cedrus deodara

Aspergillus terreus

2 references

Asperterrestide A, a cytotoxic cyclic tetrapeptide from the marine-derived fungus Aspergillus terreus SCSGAF0162.

Aspeterreurone A, a Cytotoxic Dihydrobenzofuran-Phenyl Acrylate Hybrid from the Deep-Sea-Derived Fungus Aspergillus terreus CC-S06-18

Rhizopycnis vagum

1 reference

Bioactive Dibenzo-α-pyrone Derivatives from the Endophytic Fungus Rhizopycnis vagum Nitaf22.

Ophioparma ventosa

1 reference

Minor Pyranonaphthoquinones from the Apothecia of the Lichen Ophioparma ventosa

Aspergillus flavus

1 reference

Sesquiterpenes from an Endophytic Aspergillus flavus

Albizia coriaria

1 reference

Cytotoxic acacic acid glycosides from the roots of Albizia coriaria

Chlorophytum borivilianum

1 reference

Cytotoxic spirostane-type saponins from the roots of Chlorophytum borivilianum

Penicillium brocae

1 reference

Brocazines A-F, Cytotoxic Bisthiodiketopiperazine Derivatives from Penicillium brocae MA-231, an Endophytic Fungus Derived from the Marine Mangrove Plant Avicennia marina

Stachybotrys chartarum

1 reference

Stachybotrysins A-G, Phenylspirodrimane Derivatives from the Fungus Stachybotrys chartarum.

Penicillium concentricum

1 reference

Halogenated Compounds from Directed Fermentation of Penicillium concentricum, an Endophytic Fungus of the Liverwort Trichocolea tomentella

Casearia membranacea

1 reference

New cytotoxic clerodane diterpenoids from the leaves and twigs of Casearia membranacea

Chaetomium globosum

2 references

Armochaetoglobins A–J: Cytochalasan Alkaloids from Chaetomium globosum TW1-1, a Fungus Derived from the Terrestrial Arthropod Armadillidium vulgare

Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus Chaetomium globosum MP4-S01-7

Chaetomium elatum

1 reference

Xanthoquinodins from the Endolichenic Fungal Strain Chaetomium elatum

Trichoderma velutinum

1 reference

Lipovelutibols A-D: Cytotoxic Lipopeptaibols from the Himalayan Cold Habitat Fungus Trichoderma velutinum

Penicillium aurantiacobrunneum

1 reference

α-Pyrone and Sterol Constituents of Penicillium aurantiacobrunneum, a Fungal Associate of the Lichen Niebla homalea

Taxus cuspidata var. nana

1 reference

Taxuspinananes A and B, new taxoids from Taxus cuspidata var. nana

Acrocalymma vagum

1 reference

Bioactive Dibenzo-α-pyrone Derivatives from the Endophytic Fungus Rhizopycnis vagum Nitaf22.

Taxus wallichiana

24 references

Novel taxane diterpenes from Taxus sumatrana with the first C-21 taxane ester

Taxol and its related taxoids from the needles of Taxus sumatrana.

Chemical Study of Indonesian Medicinal Plants

Novel Taxane Diterpenes from Taxus sumatrana with the First C-21 Taxane Ester

High Performance Liquid Chromatographic Determination of Taxol and Related Taxanes from Taxus Callus Cultures

Improved Taxol Yield in Cell Suspension Culture of Taxus wallichiana (Himalayan Yew)

Semi-Preparative Separation and Purification of Taxol Analogs by High-Speed Countercurrent Chromatography

Analysis of taxol and major taxoids in Himalayan yew, Taxus wallichiana

Variation in content of taxol and related taxanes in Eastern Himalayan populations of Taxus wallichiana

Wallifoliol, a taxol congener with a novel carbon skeleton, from Himalayan Taxus wallichiana

Taxoids from the barks of Taxus wallichiana

A New Taxane Diterpene fromTaxus yunnanensis

New taxane diterpenoids from the leaves and twigs of Taxus sumatrana

Diterpenes and sesquiterpenes from the bark of Taxus yunnanensis

New Taxane Diterpenoids from Taxus yunnanensis

Chemical constituents of Taxus species

The taxoid constituents of the roots of Taxus wallichiana

Production of Paclitaxel and Baccatin III in a 20-L Airlift Bioreactor by a Cell Suspension of Taxus wallichiana

LARGE-SCALE PROCESS FOR HIGH PURITY TAXOL FROM BARK EXTRACT OFTAXUS YUNNANESIS

A Large Scale Separation of Taxanes from the Bark Extract of Taxus yunnanesis and 1H- and 13C-NMR Assignments for 7-epi-10-Deacetyltaxol

Stimulation of taxol production and excretion in Taxus spp cell cultures by rare earth chemical lanthanum

High Performance Liquid Chromatographic Determination of Taxol and Related Taxanes from Texas Callus Cultures

Constituents from Taxus species

Taxus cuspidata

49 references

Methodology for the Identification and Purification of Taxol and Cephalomannine from Taxus Callus Cultures

Taxol on the surface of leaves and inside the needles of three species and two varieties of Taxus

Microwave-Assisted Extraction of Taxanes fromTaxusBiomass

Sample preparation for taxol and cephalomannine determination in various organs of Taxus sp

High Performance Liquid Chromatographic Determination of Taxol and Related Taxanes from Taxus Callus Cultures

Taxol production in suspension cultures of Taxus baccata

Distribution and amounts of taxol in different shoot parts of Taxus cuspidata

Qualitative and quantitative determination of taxol and related compounds inTaxus cuspidata Sieb et Zucc

Roots of hydroponically grown Taxus plants as a source of taxol and related taxanes

Continuous production of taxol by cell culture of taxus cuspidata.

Recycling High-Speed Countercurrent Chromatography for Separation of Taxol and Cephalomannine

Concentrations of taxol and related taxanes in the needles of differentTaxus cultivars

Studies on factors influencing stability and recovery of paclitaxel from suspension media and cultures of Taxus cuspidata cv Densiformis by high-performance liquid chromatography

Yew (Taxus) Species - Chemical And Morphological Variations

Neutral and basic taxoid contents in the needles of Taxus species

Efficient Paclitaxel Production using Protoplasts Isolated from Cultured Cells of Taxus cuspidata

Taxus spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia: analysis and isolation

Taxol content in bark, wood, root, leaf, twig, and seedling from several Taxus species

Determination of taxol by high-performance liquid chromatography-thermospray mass spectrometry

Effects of genetic, epigenetic, and environmental factors on taxol content in Taxus brevifolia and related species

Taxuspines A ∼ C, new taxoids from Japanese yew Taxus cuspidata inhibiting drug transport activity of P-glycoprotein in multidrug-resistant cells

Taxuspines E ∼ H and J, new taxoids from the Japanese yew Taxus cuspidata

A taxoid from Taxus cuspidata var. nana

A taxoid from the needles of the Japanese yew, Taxus cuspidata

A Novel Rearranged Taxoid from Needles of the Japanese Yew, Taxus cuspidata Sieb. et Zucc

Taxol content in the seeds of Taxus SPP

Effects of taxoids from Taxus cuspidata on microtubule depolymerization and vincristine accumulation in MDR cells

Supercritical fluid extraction of paclitaxel and baccatin III from needles of taxus cuspidata

Taxol (paclitaxel) production using free and immobilized cells of Taxus cuspidata

Accelerated solvent extraction of paclitaxel and related compounds from the bark of taxus cuspidata

A Novel Method of Isolating Taxanes from Cell Suspension Cultures of Yew (TaxusSpp.)

Taxol

Supercritical fluid extraction of taxol and baccatin III from needles of Taxus cuspidata

RECOVERY OF TAXOL FROM THE EXTRACT OF TAXUS CUSPIDATE CALLUS CULTURES WITH AL2O3 CHROMATOGRAPHY

Kinetics of two-liquid-phase Taxus cuspidata cell culture for production of Taxol

Purification of S-PG05 using Simulated Moving Bed Chromatography

Large-scale growth and taxane production in cell cultures of Taxus cuspidata (Japanese yew) using a novel bioreactor

Immunocytochemical Localization of Taxol in Taxus cuspidata

Rapid screening for taxanes by tandem mass spectrometry

Improved growth and taxol yield in developing calli of Taxus cuspidata by medium composition modification.

Influence of water extracts from the surface of two yew (Taxus) species on mites (Tetranychus urticae)

Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesis

Taxol biosynthesis: differential transformations of taxadien-5 alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells

Taxol biosynthesis: Taxane 13α-hydroxylase is a cytochrome P450-dependent monooxygenase

Taxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane 2alpha-O-benzoyltransferase cDNA from taxus and functional expression in Escherichia coli

High Performance Liquid Chromatographic Determination of Taxol and Related Taxanes from Texas Callus Cultures

Taxol production in nodule cultures of Taxus

Sporormiella minima

1 reference

Evidence for paclitaxel from three new endophytic fungi of Himalayan yew of Nepal

Dioscorea communis

1 reference

Rapid screening for taxanes by tandem mass spectrometry

Taxus

7 references

Analysis of taxol and related diterpenoids from cell cultures by liquid chromatography-electrospray mass spectrometry

High-performance liquid chromatography and micellar electrokinetic chromatography of taxol and related taxanes from bark and needle extracts of Taxus species

A simplified method for the determination of taxanes in yew needles by reversed-phase (C18) high pressure liquid chromatography

Taxanes from Taxus x media

Paclitaxel Analogues fromTaxus×mediacv. Hicksii

PREPARATIVE CHROMATOGRAPHIC SEPARATION OF TAXOL FROM YEW TREES

Adsorption characteristics and separation of taxol from yew tree by NP-HPLC

Calothrix (illegit. fungus)

1 reference

Calothrixamides A and B from the Cultured CyanobacteriumCalothrixsp. UIC 10520

Streptomyces

2 references

Dimeric Pyranonaphthoquinone Glycosides with Anti-HIV and Cytotoxic Activities from a Soil-Derived Streptomyces

Polycyclic Hybrid Isoprenoids from a Reed Rhizosphere Soil Derived Streptomyces sp. CHQ-64

Nostoc

1 reference

Merocyclophanes C and D from the Cultured Freshwater Cyanobacterium Nostoc sp. (UIC 10110).

Burkholderia

1 reference

Cytotoxic Spliceostatins from Burkholderia sp. and Their Semisynthetic Analogues

medical condition treated

1 reference

13 December 2016

1 reference

13 December 2016

1 reference

13 December 2016

1 reference

head and neck squamous cell carcinoma

13 December 2016

1 reference

2 October 2018

melanoma

1 reference

pancreatic adenocarcinoma

2 October 2018

1 reference

non-small-cell lung carcinoma

2 October 2018

1 reference

invasive ductal carcinoma

2 October 2018

1 reference

2 October 2018

gastric adenocarcinoma

1 reference

squamous cell carcinoma of the lung

2 October 2018

1 reference

2 October 2018

metastatic melanoma

1 reference

significant drug interaction

2 October 2018

trimethoprim

bone marrow failure

1 reference

hypothetically

A reference set of clinically relevant adverse drug-drug interactions

crizotinib

bone marrow failure

1 reference

hypothetically

A reference set of clinically relevant adverse drug-drug interactions

idelalisib

bone marrow failure

1 reference

hypothetically

A reference set of clinically relevant adverse drug-drug interactions

amiodarone

peripheral neuropathy

1 reference

probably

A reference set of clinically relevant adverse drug-drug interactions

fosphenytoin

peripheral neuropathy

1 reference

probably

A reference set of clinically relevant adverse drug-drug interactions

phenytoin

peripheral neuropathy

1 reference

probably

A reference set of clinically relevant adverse drug-drug interactions

physically interacts with

nuclear receptor subfamily 1 group I member 2

subject has role

agonist

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2770

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

2770

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

2770

17 August 2016

legal status (medicine)

boxed warning

1 reference

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)

pregnancy category

US pregnancy category D

1 reference

LiverTox likelihood score

English Wikipedia

LiverTox toxicity likelihood category D

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Paclitaxel

7 September 2020

1 reference

https://www.pfizer.com/products/product-list

mass

853.331 dalton

1 reference

paclitaxel (English)

18 November 2016

1 reference

1 reference

5 March 2018

1 reference

Medical Subject Headings

MeSH descriptor ID

D017239

phytogenic antineoplastic agents

15 March 2018

1 reference

Medical Subject Headings

MeSH descriptor ID

D017239

female reproductive toxicant

15 March 2018

start time

26 August 1997

1 reference

California Proposition 65 list of chemicals

18 March 2020

https://oehha.ca.gov/chemicals/paclitaxel

male reproductive toxicant

start time

26 August 1997

1 reference

California Proposition 65 list of chemicals

18 March 2020

https://oehha.ca.gov/chemicals/paclitaxel

developmental toxicant

start time

26 August 1997

1 reference

California Proposition 65 list of chemicals

18 March 2020

https://oehha.ca.gov/chemicals/paclitaxel

essential medicine

0 references

Commons category

Paclitaxel

0 references

Identifiers

National Library of Spain SpMaBN ID (BNE v1.0)

XX554373

0 references

GND ID

4351511-3

1 reference

National Library of Israel J9U ID

German Wikipedia

987007561068205171

1 reference

National Library of Israel Names and Subjects Authority File

Library of Congress authority ID

sh92003700

1 reference

InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

German Wikipedia

InChI

1 reference

paclitaxel (English)

18 November 2016

2 references

paclitaxel (English)

18 November 2016

ChEBI release 2020-09-01

CAS Registry Number

33069-62-4

2 references

Global Substance Registration System

UNII

P88XT4IS4D

paclitaxel (English)

18 November 2016

https://commonchemistry.cas.org/detail?cas_rn=33069-62-4

10 April 2021

1 reference

Paclitaxel (English)

18 November 2016

2 references

paclitaxel (English)

18 November 2016

ChEBI ID

45863

mapping relation type

3 references

PACLITAXEL (English)

18 November 2016

ChEBI release 2019-10-02

International Chemical Identifier

InChI

InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

1 reference

PACLITAXEL (English)

18 November 2016

2 references

inferred from InChIKey

1 reference

MassBank accession ID

MSBNK-NaToxAq-NA002484

1 reference

MassBank/MassBank-data: release version 2022.06 to wikidata

4 September 2022

based on heuristic

InChIKey match

MSBNK-NaToxAq-NA002485

1 reference

MassBank/MassBank-data: release version 2022.06 to wikidata

4 September 2022

splash10-0ui8-0000040490-593985dd09205a47de7b

0 references

splash10-0a4i-0971000000-ce9cc1a2f9862b777afc

0 references

splash10-0a4i-0549170030-03c386b612e0993c9ae4

0 references

0 references

1 reference

Hazardous Substances Data Bank

28 October 2019

TAXOL (English)

10 May 2021

2 references

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

DSSTOX compound identifier

0 references

0 references

0 references

0 references

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.127.725

27 December 2018

ECHA Substance Infocard ID

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca(3,4)benz(1,2-b)oxet-5-one 6,12b-diacetate, 12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine (English)

quotation

CAS no.: 33069-62-4 (English)

100.127.725

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.127.725

27 December 2018

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca(3,4)benz(1,2-b)oxet-5-one 6,12b-diacetate, 12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine (English)

quotation

CAS no.: 33069-62-4 (English)

1 reference