Structural analysis of caspase-1 inhibitors derived from Tethering. (Q42411842)

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17 January 2020

title

Structural analysis of caspase-1 inhibitors derived from Tethering (English)

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17 January 2020

1

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Bruce T Fahr

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Michael J Romanowski

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Joni W Lam

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Hans E Purkey

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17 January 2020

author name string

Michelle M Sopko

3

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17 January 2020

Nathan D Waal

5

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Brian C Raimundo

6

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17 January 2020

Phuongly Pham

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publication date

9 April 2005

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Acta Crystallographica Section F: Structural Biology Communications

17 January 2020

published in

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17 January 2020

volume

61

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17 January 2020

issue

Pt 5

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page(s)

451-458

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Molecular mechanisms of caspase regulation during apoptosis

17 January 2020

cites work

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Refinement of macromolecular structures by the maximum-likelihood method

28 May 2018

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Making drugs on proteins: site-directed ligand discovery for fragment-based lead assembly

28 May 2018

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Tethering: fragment-based drug discovery

28 May 2018

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Prospects for caspase inhibitors.

28 May 2018

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Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2

28 May 2018

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In situ assembly of enzyme inhibitors using extended tethering

28 May 2018

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Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design

28 May 2018

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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

28 May 2018

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Implementation of molecular replacement in AMoRe

28 May 2018

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Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions

28 May 2018

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The finer things in X-ray diffraction data collection

28 May 2018

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Incorporation of prior phase information strengthens maximum-likelihood structure refinement

28 May 2018

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Efficient anisotropic refinement of macromolecular structures using FFT

28 May 2018

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SFCHECK: a unified set of procedures for evaluating the quality of macromolecular structure-factor data and their agreement with the atomic model

28 May 2018

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Autoproteolytic activation of pro-caspases by oligomerization

28 May 2018

1 reference

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Proteases, proteolysis, and apoptosis

28 May 2018

1 reference

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A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)

28 May 2018

1 reference

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Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme

28 May 2018

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Structure and mechanism of interleukin-1 beta converting enzyme

28 May 2018

1 reference

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Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

28 May 2018

1 reference

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Interleukin-1 beta converting enzyme requires oligomerization for activity of processed forms in vivo

28 May 2018

1 reference

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Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

28 May 2018

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Improved methods for building protein models in electron density maps and the location of errors in these models

28 May 2018

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A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

28 May 2018

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Molecular cloning of the interleukin-1 beta converting enzyme

28 May 2018

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Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding.

28 May 2018

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Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.

16 August 2018

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Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production.

16 August 2018

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Expression, refolding, and autocatalytic proteolytic processing of the interleukin-1 beta-converting enzyme precursor

16 August 2018

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Identification of potent and novel small-molecule inhibitors of caspase-3

16 August 2018

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12 December 2020

High-throughput screening of enzyme inhibitors: simultaneous determination of tight-binding inhibition constants and enzyme concentration

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12 December 2020

IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha

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12 December 2020

Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme

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12 December 2020

Preparation and evaluation of peptidic aspartyl hemiacetals as reversible inhibitors of interleukin-1 beta converting enzyme (ICE)

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12 December 2020

10.1107/S1744309105010109

Identifiers

DOI

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17 January 2020

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17 January 2020

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