Nucleic acid sensing by T cells initiates Th2 cell differentiation (Q42220060)

18 October 2017

Nucleic acid sensing by T cells initiates Th2 cell differentiation (English)

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18 October 2017

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Shizuo Akira

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author name string

Takayuki Imanishi

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18 October 2017

Chitose Ishihara

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18 October 2017

Mohamed El Sherif Gadelhaq Badr

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18 October 2017

Yayoi Kimura

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18 October 2017

Taro Kawai

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Osamu Takeuchi

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Shun'ichiro Taniguchi

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Tetsuo Noda

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Hisashi Hirano

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18 October 2017

Frank Brombacher

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Glen N Barber

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18 October 2017

language of work or name

English

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publication date

10 April 2014

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18 October 2017

Nature Communications

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18 October 2017

5

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18 October 2017

3566

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https://scigraph.springernature.com/pub.10.1038/ncomms4566

18 October 2017

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Toll-like receptors and innate immunity

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

TLR2 is expressed on activated T cells as a costimulatory receptor

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Toll-like receptor 2 controls expansion and function of regulatory T cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Toll-like receptor 2 signaling in CD4(+) T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4+ T cells.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Toll-like receptor ligands directly promote activated CD4+ T cell survival

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Differentiation of effector CD4 T cell populations (*)

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

How are T(H)2-type immune responses initiated and amplified?

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Phosphodiester CpG oligonucleotides as adjuvants: polyguanosine runs enhance cellular uptake and improve immunostimulative activity of phosphodiester CpG oligonucleotides in vitro and in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Structures for polyinosinic acid and polyguanylic acid

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Neutrophils in the activation and regulation of innate and adaptive immunity

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4566

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Chronic melatonin treatment and the hypothalamo-pituitary-adrenal axis in the rat: attenuation of the secretory response to stress and effects on hypothalamic neuropeptide content and release.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Activation of MDA5 requires higher-order RNA structures generated during virus infection

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

How microorganisms tip the balance between interleukin-12 family members

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4566

IL-2 and autocrine IL-4 drive the in vivo development of antigen-specific Th2 T cells elicited by nematode parasites

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

DNA released from dying host cells mediates aluminum adjuvant activity

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

TLR2 engagement on CD8 T cells lowers the thresholdfor optimal antigen-induced T cell activation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

Cutting edge: TLR2 directly triggers Th1 effector functions

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

7 January 2021

Spontaneous Formation of Nucleic Acid-based Nanoparticles Is Responsible for High Interferon-α Induction by CpG-A in Plasmacytoid Dendritic Cells

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

7 January 2021

Intramolecular G-quartet motifs confer nuclease resistance to a potent anti-HIV oligonucleotide

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

7 January 2021

Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

7 January 2021

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4566

7 January 2021

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4566

7 January 2021

Conventional, naive CD4+ T cells provide an initial source of IL-4 during Th2 differentiation

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

7 January 2021

The IL-4 production capability of different strains of naive CD4(+) T cells controls the direction of the T(h) cell response

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https://api.crossref.org/works/10.1038%2FNCOMMS4566

7 January 2021

Identifiers

DOI

10.1038/NCOMMS4566

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18 October 2017

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