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C-X-C motif chemokine ligand 8 (Q421859)

From Wikidata

mammalian protein found in Homo sapiens

CXCL8
monocyte-derived neutrophil chemotactic factor
T-cell chemotactic factor
interleukin-8
MONAP
lymphocyte derived neutrophil activating peptide
NAP-1
C-X-C motif chemokine 8
emoctakin
lung giant cell carcinoma-derived chemotactic protein
monocyte-derived neutrophil-activating peptide
neutrophil-activating peptide 1
GCP-1
chemokine (C-X-C motif) ligand 8
Neutrophil-activating protein 1
tumor necrosis factor-induced gene 1
interleukin 8
MDNCF
Protein 3-10C
beta-thromboglobulin-like protein
beta endothelial cell-derived neutrophil activating peptide
granulocyte chemotactic protein 1
small inducible cytokine subfamily B, member 8
alveolar macrophage chemotactic factor I
chemokine ligand 8

Language	Label	Description	Also known as
default for all languages	No label defined
English	C-X-C motif chemokine ligand 8	mammalian protein found in Homo sapiens	CXCL8 monocyte-derived neutrophil chemotactic factor T-cell chemotactic factor interleukin-8 MONAP lymphocyte derived neutrophil activating peptide NAP-1 C-X-C motif chemokine 8 emoctakin lung giant cell carcinoma-derived chemotactic protein monocyte-derived neutrophil-activating peptide neutrophil-activating peptide 1 GCP-1 chemokine (C-X-C motif) ligand 8 Neutrophil-activating protein 1 tumor necrosis factor-induced gene 1 interleukin 8 MDNCF Protein 3-10C beta-thromboglobulin-like protein beta endothelial cell-derived neutrophil activating peptide granulocyte chemotactic protein 1 small inducible cytokine subfamily B, member 8 alveolar macrophage chemotactic factor I chemokine ligand 8

Statements

1 reference

13 November 2019

UniProt protein ID

Chemokine interleukin-8-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10145

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10145

Chemokine interleukin-8-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CXC Chemokine domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CXC chemokine, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

IL8 Solution Structure.rsh.png
900 × 750; 214 KB

0 references

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

cytokine activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

protein binding

determination method or standard

7 references

8 April 2019

Involvement of alpha-2-macroglobulin receptor in clearance of interleukin 8-alpha-2-macroglobulin complexes by human alveolar macrophages

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

Mycobacterium tuberculosis AtsG (Rv0296c), GlmU (Rv1018c) and SahH (Rv3248c) Proteins Function as the Human IL-8-Binding Effectors and Contribute to Pathogen Entry into Human Neutrophils

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

Mycobacterium tuberculosis AtsG (Rv0296c), GlmU (Rv1018c) and SahH (Rv3248c) Proteins Function as the Human IL-8-Binding Effectors and Contribute to Pathogen Entry into Human Neutrophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

chemokine activity

determination method or standard

4 references

16 July 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

determination method or standard

16 July 2018

Autocrine growth effect of IL-8 and GROalpha on a human pancreatic cancer cell line, Capan-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

determination method or standard

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

determination method or standard

16 July 2018

Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

determination method or standard

chemokine activity

determination method or standard

5 references

8 April 2019

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

Autocrine growth effect of IL-8 and GROalpha on a human pancreatic cancer cell line, Capan-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

extracellular region

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

determination method or standard

extracellular space

determination method or standard

3 references

8 April 2019

Inflammation in the developing human intestine: A possible pathophysiologic contribution to necrotizing enterocolitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

biological process

intracellular signal transduction

determination method or standard

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

chemokine-mediated signaling pathway

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

cellular response to tumor necrosis factor

determination method or standard

1 reference

8 April 2019

Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

receptor internalization

determination method or standard

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

cellular response to fibroblast growth factor stimulus

determination method or standard

1 reference

8 April 2019

Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

response to endoplasmic reticulum stress

determination method or standard

1 reference

8 April 2019

Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

positive regulation of angiogenesis

determination method or standard

1 reference

8 April 2019

CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

regulation of single stranded viral RNA replication via double stranded DNA intermediate

determination method or standard

1 reference

8 April 2019

Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

PERK-mediated unfolded protein response

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

induction of positive chemotaxis

determination method or standard

1 reference

8 April 2019

Immobilized IL-8 triggers progressive activation of neutrophils rolling in vitro on P-selectin and intercellular adhesion molecule-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

determination method or standard

3 references

8 April 2019

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

regulation of cell adhesion

determination method or standard

1 reference

8 April 2019

Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

cellular response to interleukin-1

determination method or standard

1 reference

8 April 2019

Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

determination method or standard

1 reference

8 April 2019

Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

positive regulation of neutrophil chemotaxis

determination method or standard

1 reference

8 April 2019

Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

inflammatory response

determination method or standard

3 references

16 July 2018

Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

determination method or standard

16 July 2018

Inflammation in the developing human intestine: A possible pathophysiologic contribution to necrotizing enterocolitis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

determination method or standard

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

determination method or standard

negative regulation of G protein-coupled receptor signaling pathway

determination method or standard

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

response to molecule of bacterial origin

determination method or standard

1 reference

8 April 2019

A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

cellular response to lipopolysaccharide

determination method or standard

1 reference

16 July 2018

A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

determination method or standard

embryonic digestive tract development

determination method or standard

1 reference

8 April 2019

TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

signal transduction

determination method or standard

1 reference

8 April 2019

Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

negative regulation of cell population proliferation

determination method or standard

1 reference

8 April 2019

CXC chemokines suppress proliferation of myeloid progenitor cells by activation of the CXC chemokine receptor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

calcium-mediated signaling

determination method or standard

1 reference

8 April 2019

Ca(2+) signalling by recombinant human CXCR2 chemokine receptors is potentiated by P2Y nucleotide receptors in HEK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

regulation of entry of bacterium into host cell

determination method or standard

1 reference

8 April 2019

Mycobacterium tuberculosis AtsG (Rv0296c), GlmU (Rv1018c) and SahH (Rv3248c) Proteins Function as the Human IL-8-Binding Effectors and Contribute to Pathogen Entry into Human Neutrophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

defense response

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

neutrophil chemotaxis

determination method or standard

3 references

16 July 2018

Immobilized IL-8 triggers progressive activation of neutrophils rolling in vitro on P-selectin and intercellular adhesion molecule-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

determination method or standard

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

determination method or standard

16 July 2018

Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

determination method or standard

neutrophil activation

determination method or standard

3 references

8 April 2019

Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

antimicrobial humoral immune response mediated by antimicrobial peptide

determination method or standard

1 reference

27 February 2018

Potent and broad-spectrum antimicrobial activity of CXCL14 suggests an immediate role in skin infections.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

determination method or standard

regulation of signaling receptor activity

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

cytokine-mediated signaling pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

inflammatory response

determination method or standard

4 references

8 April 2019

Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

Inflammation in the developing human intestine: A possible pathophysiologic contribution to necrotizing enterocolitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

neutrophil chemotaxis

determination method or standard

4 references

8 April 2019

Immobilized IL-8 triggers progressive activation of neutrophils rolling in vitro on P-selectin and intercellular adhesion molecule-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

leukocyte chemotaxis

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

antimicrobial humoral immune response mediated by antimicrobial peptide

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

determination method or standard

cellular response to lipopolysaccharide

determination method or standard

Gene Atlas image

PBB GE IL8 211506 s at.png
255 × 135; 556 bytes

1 reference

imported from Wikimedia project

English Wikipedia

http://purl.uniprot.org/uniprot/P10145

1 reference

Identifiers.org

Chemokine interleukin-8-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10145

CXC chemokine, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10145

CXC Chemokine domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10145

Identifiers

1 reference

https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:138181

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000306512

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000306512

ENSP00000385908

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000385908

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID (discontinued)

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(23 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(1 entry)

commonswiki Category:Interleukin-8

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