Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain (Q42156703)

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English	Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain	scientific article

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scholarly article

1 reference

Europe PubMed Central

17 October 2017

Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain (English)

1 reference

Europe PubMed Central

17 October 2017

1 reference

based on heuristic

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author name string

Hidefumi Oshita

1

1 reference

Europe PubMed Central

17 October 2017

John D Sandy

2

1 reference

Europe PubMed Central

17 October 2017

Kiichi Suzuki

3

1 reference

Europe PubMed Central

17 October 2017

Atsushi Akaike

4

1 reference

Europe PubMed Central

17 October 2017

Yun Bai

5

1 reference

Europe PubMed Central

17 October 2017

Tomohiro Sasaki

6

1 reference

Europe PubMed Central

17 October 2017

Katsuji Shimizu

7

1 reference

Europe PubMed Central

17 October 2017

language of work or name

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publication date

1 August 2004

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Europe PubMed Central

17 October 2017

Biochemical Journal

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Europe PubMed Central

17 October 2017

382

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Europe PubMed Central

17 October 2017

Pt 1

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Europe PubMed Central

17 October 2017

253-259

1 reference

Europe PubMed Central

17 October 2017

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Association of the calpain/calpastatin network with subcellular organelles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Glycation induced crosslinking of link proteins, in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Mechanisms involved in cartilage proteoglycan catabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Characterization of aggrecan retained and lost from the extracellular matrix of articular cartilage. Involvement of carboxyl-terminal processing in the catabolism of aggrecan.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Complete coding sequence of bovine aggrecan: comparative structural analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Interaction of cartilage matrix protein with aggrecan. Increased covalent cross-linking with tissue maturation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Proteoglycans isolated from dissociative extracts of differently aged human articular cartilage: characterization of naturally occurring hyaluronan-binding fragments of aggrecan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Appearance of calpain correlates with arthritis and cartilage destruction in collagen induced arthritic knee joints of mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Separation and characterization of two populations of aggregating proteoglycans from cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Production and characterization of monoclonal antibodies directed against connective tissue proteoglycans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Activation of neutrophil calpain following its translocation to the plasma membrane induced by phorbol ester or fMet-Leu-Phe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Calcium-dependent cysteine proteinase (calpain) in human arthritic synovial joints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Cartilage proteoglycans. Structure and heterogeneity of the protein core and the effects of specific protein modifications on the binding to hyaluronate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

29 May 2018

Aggrecan protects cartilage collagen from proteolytic cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

17 August 2018

The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

17 August 2018

Age-related accumulation of the advanced glycation endproduct pentosidine in human articular cartilage aggrecan: the use of pentosidine levels as a quantitative measure of protein turnover

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

17 August 2018

Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing i

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

17 August 2018

The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

17 August 2018

Cathepsin B: an alternative protease for the generation of an aggrecan 'metalloproteinase' cleavage neoepitope

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

17 August 2018

m-calpain in rat growth plate chondrocyte cultures: its involvement in the matrix mineralization process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

17 August 2018

Identification of a monoclonal antibody that specifically recognizes corneal and skeletal keratan sulfate. Monoclonal antibodies to cartilage proteoglycan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133938

3 November 2018

Electrophoresis of 35S-labeled proteoglycans on polyacrylamide-agarose composite gels and their visualization by fluorography

1 reference

https://pubmed.ncbi.nlm.nih.gov/15175011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the hyaluronate binding properties of newly synthesized proteoglycans purified from articular chondrocyte cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/15175011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/15175011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical demonstration of calcium-dependent cysteine proteinase (calpain) in collagen-induced arthritis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15175011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of matrix synthesis in isolated bovine chondrocytes by extracellular and intracellular pH

1 reference

https://pubmed.ncbi.nlm.nih.gov/15175011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathways of aggrecan processing in joint tissues. Implications for disease mechanism and monitoring

1 reference

https://pubmed.ncbi.nlm.nih.gov/15175011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MMP-8 (neutrophil collagenase) mRNA and aggrecanase cleavage products are present in normal and osteoarthritic human articular cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/15175011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Externalization of calpain (calcium-dependent neutral cysteine proteinase) in human arthritic cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/15175011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition of articular cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/15175011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chondrocyte extracellular matrix synthesis and turnover are influenced by static compression in a new alginate disk culture system

1 reference

https://pubmed.ncbi.nlm.nih.gov/15175011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intact aggrecan and fragments generated by both aggrecanse and metalloproteinase-like activities are present in the developing and adult rat spinal cord and their relative abundance is altered by injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/15175011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteoglycans from bovine proximal humeral articular cartilage. Structural basis for the polydispersity of proteoglycan subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/15175011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ20040113

0 references

1 reference

Europe PubMed Central

17 October 2017

1 reference

Europe PubMed Central

17 October 2017

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