Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. (Q42115604)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27435960%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

title

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch (English)

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19 March 2020

9

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19 March 2020

Peter Walter

12

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19 March 2020

author name string

Ciara M Gallagher

1

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19 March 2020

Carolina Garri

2

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19 March 2020

Erica L Cain

3

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19 March 2020

Kenny Kean-Hooi Ang

4

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19 March 2020

Christopher G Wilson

5

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19 March 2020

Steven Chen

6

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19 March 2020

Brian R Hearn

7

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19 March 2020

Priyadarshini Jaishankar

8

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19 March 2020

Michelle R Arkin

10

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19 March 2020

Adam R Renslo

11

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19 March 2020

language of work or name

English

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publication date

20 July 2016

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19 March 2020

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19 March 2020

volume

5

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describes a project that uses

19 March 2020

CellProfiler

object named as

CellProfiler

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

CellProfiler

0 references

cites work

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Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic

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Controlling the unfolded protein response-mediated life and death decisions in cancer.

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Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy

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The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

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Druggable sensors of the unfolded protein response

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Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain

29 May 2018

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Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

29 May 2018

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Quality control: ER-associated degradation: protein quality control and beyond

29 May 2018

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Pharmacological brake-release of mRNA translation enhances cognitive memory

29 May 2018

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Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases

29 May 2018

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Protein folding in the endoplasmic reticulum

29 May 2018

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Endoplasmic reticulum stress sensing in the unfolded protein response

29 May 2018

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The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

29 May 2018

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Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis

29 May 2018

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A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism

29 May 2018

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Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation

29 May 2018

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New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

29 May 2018

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In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles

29 May 2018

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Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

29 May 2018

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ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo

29 May 2018

1 reference

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Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals

29 May 2018

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Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization

29 May 2018

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Coupling cystic fibrosis to endoplasmic reticulum stress: Differential role of Grp78 and ATF6.

29 May 2018

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IRE1 signaling affects cell fate during the unfolded protein response

29 May 2018

1 reference

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ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress

29 May 2018

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XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks

29 May 2018

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XIST RNA exhibits nuclear retention and exhibits reduced association with the export factor TAP/NXF1.

29 May 2018

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CellProfiler: image analysis software for identifying and quantifying cell phenotypes

29 May 2018

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Activation of mammalian unfolded protein response is compatible with the quality control system operating in the endoplasmic reticulum

29 May 2018

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Herp is dually regulated by both the endoplasmic reticulum stress-specific branch of the unfolded protein response and a branch that is shared with other cellular stress pathways

29 May 2018

1 reference

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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

29 May 2018

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A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

Regulation of the mevalonate pathway

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954757

Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.7554%2FELIFE.11878

Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II

21 January 2018

1 reference

12 December 2020

Aminopyrrolidineamide inhibitors of site-1 protease

1 reference

12 December 2020

Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1

1 reference

12 December 2020

ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum

1 reference

12 December 2020

Identifiers

DOI

10.7554/ELIFE.11878

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27435960%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27435960%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference