Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1. (Q42051446)

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scientific article published on October 2003

Language	Label	Description	Also known as
English	Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1.	scientific article published on October 2003

Statements

scholarly article

1 reference

Europe PubMed Central

15 October 2017

Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1. (English)

1 reference

Europe PubMed Central

15 October 2017

author name string

Claire J Chalmers

1

1 reference

Europe PubMed Central

15 October 2017

Kathryn Balmanno

2

1 reference

Europe PubMed Central

15 October 2017

Kathryn Hadfield

3

1 reference

Europe PubMed Central

15 October 2017

Rebecca Ley

4

1 reference

Europe PubMed Central

15 October 2017

Simon J Cook

5

1 reference

Europe PubMed Central

15 October 2017

language of work or name

0 references

publication date

1 October 2003

1 reference

Europe PubMed Central

15 October 2017

Biochemical Journal

1 reference

Europe PubMed Central

15 October 2017

375

1 reference

Europe PubMed Central

15 October 2017

Pt 1

1 reference

Europe PubMed Central

15 October 2017

99-109

1 reference

Europe PubMed Central

15 October 2017

Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223666

5 June 2018

Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223666

5 June 2018

The Bcl2 family: regulators of the cellular life-or-death switch

1 reference

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5 June 2018

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

1 reference

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5 June 2018

Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals

1 reference

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PUMA, a novel proapoptotic gene, is induced by p53

1 reference

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Mechanisms of cell death in primary cortical neurons and PC12 cells

1 reference

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New tricks for old dogs: nonthrombotic effects of thrombin in vessel wall biology

1 reference

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5 June 2018

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

1 reference

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5 June 2018

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

1 reference

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5 June 2018

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

1 reference

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5 June 2018

Thrombin inhibits apoptosis of monocytes and plasminogen activator inhibitor 2 (PAI-2) is not responsible for this inhibition

1 reference

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5 June 2018

Thrombin signalling and protease-activated receptors

1 reference

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Rsk1 mediates a MEK-MAP kinase cell survival signal

1 reference

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Cellular survival: a play in three Akts

1 reference

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5 June 2018

A rho exchange factor mediates thrombin and Galpha(12)-induced cytoskeletal responses

1 reference

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Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells

1 reference

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

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C3 toxin activates the stress signaling pathways, JNK and p38, but antagonizes the activation of AP-1 in rat-1 cells

1 reference

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Thrombin is an extracellular signal that activates intracellular death protease pathways inducing apoptosis in model motor neurons

1 reference

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

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Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities.

1 reference

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Kinetic and biochemical correlation between sustained p44ERK1 (44 kDa extracellular signal-regulated kinase 1) activation and lysophosphatidic acid-stimulated DNA synthesis in Rat-1 cells.

1 reference

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5 June 2018

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223666

5 June 2018

The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223666

5 June 2018

Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

1 reference

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A requirement for Ras protein function in thrombin-stimulated mitogenesis in astrocytoma cells

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Differential activation of p44mapk (ERK1) by alpha-thrombin and thrombin-receptor peptide agonist

1 reference

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Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor

1 reference

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Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts

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Pertussis toxin inhibits thrombin-induced activation of phosphoinositide hydrolysis and Na+/H+ exchange in hamster fibroblasts

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

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Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not Go to S phase progression in hamster fibroblasts. Comparison of thrombin and carbachol action in cells expressing M1 muscarinic acetylcholine recepto

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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

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Synthetic alpha-thrombin receptor peptides activate G protein-coupled signaling pathways but are unable to induce mitogenesis

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The protective effect of phorbol esters on Fas-mediated apoptosis in T cells. Transcriptional and postranscriptional regulation.

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Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults.

1 reference

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cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization.

1 reference

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Signaling pathways involved in thrombin-induced cell protection

1 reference

https://pubmed.ncbi.nlm.nih.gov/12844349

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Thrombin perturbs neurite outgrowth and induces apoptotic cell death in enriched chick spinal motoneuron cultures through caspase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12844349

12 December 2020

based on heuristic

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Thrombin, a Survival Factor for Cultured Myoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/12844349

12 December 2020

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inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase activity regulates alpha -thrombin-stimulated G1 progression by its effect on cyclin D1 expression and cyclin-dependent kinase 4 activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12844349

12 December 2020

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Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12844349

12 December 2020

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Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12844349

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ20030346

1 reference

Europe PubMed Central

15 October 2017

1 reference

Europe PubMed Central

15 October 2017

1 reference

Europe PubMed Central

15 October 2017

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