Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability. (Q42018929)

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scientific article published on 7 April 2007

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English	Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability.	scientific article published on 7 April 2007

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scholarly article

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30 December 2019

Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability (English)

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30 December 2019

thiamine deficiency

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based on heuristic

inferred from title

4

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30 December 2019

author name string

Q Shi

1

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30 December 2019

S S Karuppagounder

2

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30 December 2019

H Xu

3

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30 December 2019

H Chen

5

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30 December 2019

G E Gibson

6

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30 December 2019

publication date

7 April 2007

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30 December 2019

Neurochemistry International

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30 December 2019

50

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30 December 2019

7-8

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30 December 2019

921-931

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30 December 2019

Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism

1 reference

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5 June 2018

Thiamine deficiency induces endoplasmic reticulum stress in neurons.

1 reference

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5 June 2018

Role of mitochondrial dysfunction and oxidative stress in the pathogenesis of selective neuronal loss in Wernicke's encephalopathy

1 reference

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5 June 2018

Inhibition of the alpha-ketoglutarate dehydrogenase complex by the myeloperoxidase products, hypochlorous acid and mono-N-chloramine.

1 reference

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5 June 2018

Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity

1 reference

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Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism

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Deficits in a tricarboxylic acid cycle enzyme in brains from patients with Parkinson's disease

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5 June 2018

Oxidative stress increases internal calcium stores and reduces a key mitochondrial enzyme

1 reference

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5 June 2018

Interactions of oxidative stress with thiamine homeostasis promote neurodegeneration

1 reference

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5 June 2018

A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes

1 reference

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5 June 2018

Oxidative stress and a key metabolic enzyme in Alzheimer brains, cultured cells, and an animal model of chronic oxidative deficits

1 reference

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Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.

1 reference

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5 June 2018

Induction of nitric oxide synthase and microglial responses precede selective cell death induced by chronic impairment of oxidative metabolism

1 reference

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5 June 2018

Increased cerebral free radical production during thiamine deficiency.

1 reference

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5 June 2018

Distinct distribution of apolipoprotein E and beta-amyloid immunoreactivity in the hippocampus of Parkinson dementia complex of Guam.

1 reference

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Atm-deficient mice: a paradigm of ataxia telangiectasia

1 reference

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5 June 2018

Thiamine pyrophosphate-requiring enzymes are altered during pyrithiamine-induced thiamine deficiency in cultured human lymphoblasts

1 reference

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5 June 2018

The role of the cholinergic system in thiamin deficiency

1 reference

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5 June 2018

Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy. 2. alpha-Ketoglutarate dehydrogenase.

1 reference

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5 June 2018

Effect of age on behavioral and enzymatic changes during thiamin deficiency

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5 June 2018

Pyrithiamine as a substrate for thiamine pyrophosphokinase

1 reference

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17 August 2018

Tricarboxylic acid cycle enzymes following thiamine deficiency

1 reference

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17 August 2018

Increased brain endothelial nitric oxide synthase expression in thiamine deficiency: relationship to selective vulnerability

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17 August 2018

Reversal of thiamine deficiency-induced neurodegeneration

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17 August 2018

Abnormalities in oxidative processes in non-neuronal tissues from patients with Alzheimer's disease.

1 reference

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17 August 2018

Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy

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17 August 2018

Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress.

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Vascular factors are critical in selective neuronal loss in an animal model of impaired oxidative metabolism.

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17 August 2018

Quantitative alpha-ketoglutarate dehydrogenase activity staining in brain sections and in cultured cells.

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17 August 2018

Oxidative stress is associated with region-specific neuronal death during thiamine deficiency.

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17 August 2018

Immunochemical characterization of the deficiency of the alpha-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain.

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17 August 2018

Regional reductions of transketolase in thiamine-deficient rat brain.

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17 August 2018

Immunoreactive levels of alpha-ketoglutarate dehydrogenase subunits in Friedreich's ataxia and spinocerebellar ataxia type 1.

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17 August 2018

Brain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease.

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17 August 2018

Correlation of enzymatic, metabolic, and behavioral deficits in thiamin deficiency and its reversal

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17 August 2018

Impairment of behavior and acetylcholine metabolism in thiamine deficiency

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12 December 2020

based on heuristic

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Regionally selective alterations in enzymatic activities and metabolic fluxes during thiamin deficiency

1 reference

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12 December 2020

based on heuristic

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Frontal lobe dysfunction in progressive supranuclear palsy: evidence for oxidative stress and mitochondrial impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/17482317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of thiamine deficiency on local cerebral glucose utilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/17482317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rotarod suitable for quantitative measurements of motor incoordination in naive mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17482317

12 December 2020

based on heuristic

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Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal

1 reference

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12 December 2020

based on heuristic

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Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia

1 reference

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Identifiers

10.1016/J.NEUINT.2007.03.010

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30 December 2019

1 reference

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30 December 2019

1 reference

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30 December 2019

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