Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the β2-adrenoceptor. (Q42001057)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25342094%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

title

Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the β2-adrenoceptor (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25342094%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25342094%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

author name string

Solveig Kälble

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25342094%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Timo Littmann

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25342094%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Takeaki Ozawa

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25342094%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Stefan Dove

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25342094%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Volkhard Kaever

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25342094%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Irving W Wainer

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25342094%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Roland Seifert

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25342094%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

publication date

24 October 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25342094%20AND%20SRC:MED&resulttype=core&format=json

Naunyn-Schmiedeberg's Archives of Pharmacology

21 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25342094%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

volume

388

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25342094%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25342094%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

page(s)

51-65

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25342094%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s00210-014-1054-5

21 February 2020

exact match

0 references

cites work

Effect of beta-agonists on inflammatory cells

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Dissociations in the effects of β2-adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: support for the concept of functional selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Divergent agonist selectivity in activating β1- and β2-adrenoceptors for G-protein and arrestin coupling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

β2-agonist therapy in lung disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Energy landscapes as a tool to integrate GPCR structure, dynamics, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Ligand-directed signalling at beta-adrenoceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Quantification of functional selectivity at the human α(1A)-adrenoceptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

The evasive nature of drug efficacy: implications for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Differential transcriptional activation in vitro by NF-kappa B/Rel proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Effects of beta2-agonists on resident and infiltrating inflammatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Comparative molecular field analysis of fenoterol derivatives: A platform towards highly selective and effective beta(2)-adrenergic receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

New concepts in pharmacological efficacy at 7TM receptors: IUPHAR review 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Signalling bias in new drug discovery: detection, quantification and therapeutic impact.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

A simple method for quantifying functional selectivity and agonist bias

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Rapid and high-sensitivity cell-based assays of protein-protein interactions using split click beetle luciferase complementation: an approach to the study of G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

The dynamic process of β(2)-adrenergic receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

How many drug targets are there?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Comparative molecular field analysis of fenoterol derivatives interacting with an agonist-stabilized form of the β₂-adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Differential signaling of the endogenous agonists at the beta2-adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Fusion proteins as model systems for the analysis of constitutive GPCR activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Functional selectivity of G-protein-coupled receptors: from recombinant systems to native human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Impedance responses reveal β₂-adrenergic receptor signaling pluridimensionality and allow classification of ligands with distinct signaling profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Visualization and quantitative analysis of G protein-coupled receptor-β-arrestin interaction in single cells and specific organs of living mice using split luciferase complementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Simulations of biased agonists in the β(2) adrenergic receptor with accelerated molecular dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Anti-inflammatory and antinociceptive effects of salbutamol on acute and chronic models of inflammation in rats: involvement of an antioxidant mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Quantification of ligand bias for clinically relevant β2-adrenergic receptor ligands: implications for drug taxonomy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Distinct interactions of human beta1- and beta2-adrenoceptors with isoproterenol, epinephrine, norepinephrine, and dopamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Therapeutic potential of β-arrestin- and G protein-biased agonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Identification of novel functionally selective κ-opioid receptor scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

β-Adrenergic receptor subtype signaling in heart: from bench to bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1054-5

The superoxide-forming NADPH oxidase of phagocytes. An enzyme system regulated by multiple mechanisms.

21 January 2018

1 reference

12 December 2020

Novel GPCR paradigms at the μ-opioid receptor

1 reference

12 December 2020

Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations

1 reference

12 December 2020

Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes

1 reference

12 December 2020

The enigma of beta2-adrenergic receptor Gi signaling in the heart: the good, the bad, and the ugly

1 reference

12 December 2020

Operational models of pharmacological agonism.

1 reference

12 December 2020

Molecular analysis of beta(2)-adrenoceptor coupling to G(s)-, G(i)-, and G(q)-proteins.

1 reference

12 December 2020

GPCR-Galpha fusion proteins: molecular analysis of receptor-G-protein coupling

1 reference

12 December 2020

10.1007/S00210-014-1054-5

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25342094%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference