Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis. (Q41992348)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

title

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Rodrigo Romero

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Volkan I Sayin

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Simranjit X Singh

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Sarah E LeBoeuf

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

Francisco J Sánchez-Rivera

31 March 2020

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Igor Dolgalev

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

John T Poirier

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Charles Rudin

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Harvey I Pass

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

28

Tyler Jacks

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

author name string

Shawn M Davidson

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Matthew R Bauer

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Triantafyllia R Karakousi

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Donald C Ellis

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Arjun Bhutkar

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Lakshmipriya Subbaraj

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Britney Martinez

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Roderick T Bronson

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Justin R Prigge

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Edward E Schmidt

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Craig J Thomas

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Chandra Goparaju

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Angela Davies

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Adriana Heguy

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Viola Allaj

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Andre L Moreira

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Matthew G Vander Heiden

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Thales Papagiannakopoulos

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

language of work or name

English

0 references

publication date

2 October 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

volume

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

page(s)

1362-1368

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nm.4407

31 March 2020

exact match

0 references

cites work

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Altered metabolite levels in cancer: implications for tumour biology and cancer therapy.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

From Krebs to clinic: glutamine metabolism to cancer therapy.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

High-throughput Phenotyping of Lung Cancer Somatic Mutations

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Whole-organism lineage tracing by combinatorial and cumulative genome editing

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

NRF2 regulates serine biosynthesis in non-small cell lung cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Rapid modelling of cooperating genetic events in cancer through somatic genome editing

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Drugging the undruggable RAS: Mission possible?

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Comprehensive molecular profiling of lung adenocarcinoma

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Antioxidants accelerate lung cancer progression in mice

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Integrated molecular analysis of clear-cell renal cell carcinoma

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Comprehensive genomic characterization of squamous cell lung cancers

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Methylation of the KEAP1 gene promoter region in human colorectal cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Targeted deletion of Nrf2 reduces urethane-induced lung tumor development in mice

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5677540

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

18 August 2018

1 reference

Stromal Expression of miR-143/145 Promotes Neoangiogenesis in Lung Cancer Development

21 January 2018

1 reference

Improved vectors and genome-wide libraries for CRISPR screening

21 January 2018

1 reference

Genome-scale CRISPR-Cas9 knockout screening in human cells

21 January 2018

1 reference

Circadian Rhythm Disruption Promotes Lung Tumorigenesis

21 January 2018

1 reference

Replacing suffix trees with enhanced suffix arrays

21 January 2018

1 reference

Identification of common molecular subsequences

21 January 2018

1 reference

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

21 January 2018

1 reference

SeqAn an efficient, generic C++ library for sequence analysis

21 January 2018

1 reference

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

21 January 2018

1 reference

Trimmomatic: a flexible trimmer for Illumina sequence data

21 January 2018

1 reference

Fast and accurate short read alignment with Burrows-Wheeler transform

21 January 2018

1 reference

Sambamba: fast processing of NGS alignment formats.

21 January 2018

1 reference

A framework for variation discovery and genotyping using next-generation DNA sequencing data

21 January 2018

1 reference

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

21 January 2018

1 reference

Chemosensitive Relapse in Small Cell Lung Cancer Proceeds through an EZH2-SLFN11 Axis.

21 January 2018

1 reference

Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology

21 January 2018

1 reference

Quantitation of Murine Stroma and Selective Purification of the Human Tumor Component of Patient-Derived Xenografts for Genomic Analysis

21 January 2018

1 reference

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

21 January 2018

1 reference

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

21 January 2018

1 reference

Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis.

21 January 2018

1 reference

limma powers differential expression analyses for RNA-sequencing and microarray studies

21 January 2018

1 reference

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

21 January 2018

1 reference

Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments

21 January 2018

1 reference

Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis

21 January 2018

1 reference

Independent component analysis uncovers the landscape of the bladder tumor transcriptome and reveals insights into luminal and basal subtypes

21 January 2018

1 reference

Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells

21 January 2018

1 reference

An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis.

21 January 2018

1 reference

The differential effects of mutant p53 alleles on advanced murine lung cancer

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Correction of 13C mass isotopomer distributions for natural stable isotope abundance

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NM.4407

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28967920%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference