Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors (Q41977319)

14 October 2017

Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors (English)

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14 October 2017

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P K Manchanda

1

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14 October 2017

G N Jones

2

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14 October 2017

A A Lee

3

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14 October 2017

D R Pringle

4

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14 October 2017

M Zhang

5

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14 October 2017

L Yu

6

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14 October 2017

K M D La Perle

7

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14 October 2017

L S Kirschner

8

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14 October 2017

language of work or name

English

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publication date

8 October 2012

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14 October 2017

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14 October 2017

32

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14 October 2017

30

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14 October 2017

3491-3499

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https://scigraph.springernature.com/pub.10.1038/onc.2012.374

14 October 2017

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cites work

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Inhibition of p21-activated kinase 6 (PAK6) increases radiosensitivity of prostate cancer cells

5 June 2018

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PAK kinase regulates Rac GTPase and is a potential target in human schwannomas

5 June 2018

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Tissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production

5 June 2018

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Small Rho GTPases are key regulators of peripheral nerve biology in health and disease.

5 June 2018

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The function of RhoGTPases in axon ensheathment and myelination

5 June 2018

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Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development

5 June 2018

1 reference

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Myelination: all about Rac 'n' roll

5 June 2018

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Shedding light on Merlin's wizardry

5 June 2018

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Germline mutation of INI1/SMARCB1 in familial schwannomatosis

5 June 2018

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Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

A Rac switch regulates random versus directionally persistent cell migration

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Of mice and MEN1: Insulinomas in a conditional mouse knockout

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Mutant products of the NF2 tumor suppressor gene are degraded by the ubiquitin-proteasome pathway

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

The evolutionary history of effectors downstream of Cdc42 and Rac.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

p21-activated kinase links Rac/Cdc42 signaling to merlin

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the carney complex

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

CD44 acts both as a growth- and invasiveness-promoting molecule and as a tumor-suppressing cofactor.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Generalized lacZ expression with the ROSA26 Cre reporter strain

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Phosphorylation of neurofibromatosis type 1 gene product (neurofibromin) by cAMP-dependent protein kinase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Development of a pituitary-specific cre line targeted to the Pit-1 lineage.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Protein kinase A-mediated phosphorylation of the NF2 tumor suppressor protein merlin at serine 10 affects the actin cytoskeleton

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Neuregulin and laminin stimulate phosphorylation of the NF2 tumor suppressor in Schwann cells by distinct protein kinase A and p21-activated kinase-dependent pathways

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

The MicroRNA let-7a modulates interleukin-6-dependent STAT-3 survival signaling in malignant human cholangiocytes.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Phosphorylation of the NF2 tumor suppressor in Schwann cells is mediated by Cdc42-Pak and requires paxillin binding.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Tyrosinase-Cre mice for tissue-specific gene ablation in neural crest and neuroepithelial-derived tissues

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Mutations of the neurofibromatosis type 2 gene and lack of the gene product in vestibular schwannomas

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542412

Contractile activity-induced transcriptional activation of cytochrome C involves Sp1 and is proportional to mitochondrial ATP synthesis in C2C12 muscle cells

18 August 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.374

What's new in neurofibromatosis? Proceedings from the 2009 NF Conference: new frontiers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.374

Cdc42 and Rac1 Signaling Are Both Required for and Act Synergistically in the Correct Formation of Myelin Sheaths in the CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.374

cAMP-dependent protein kinase A is required for Schwann cell growth: interactions between the cAMP and neuregulin/tyrosine kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.374

Retroviral inhibition of cAMP-dependent protein kinase inhibits myelination but not Schwann cell mitosis stimulated by interaction with neurons

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.374

Comparative pathology of nerve sheath tumors in mouse models and humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.374

A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.374

Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.374

Transduction of wild-type merlin into human schwannoma cells decreases schwannoma cell growth and induces apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.374

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.374

1 reference

Dimensions Publication ID

14 October 2017

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1 reference

14 October 2017

1 reference