A systems study reveals concurrent activation of AMPK and mTOR by amino acids (Q41889379)

13 October 2017

A systems study reveals concurrent activation of AMPK and mTOR by amino acids (English)

1 reference

13 October 2017

1

1 reference

13 October 2017

Björn Stork

14

0 references

Bettina Warscheid

Bettina Warscheid

12

0 references

Alexander Martin Heberle

Alexander M Heberle

6

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Kathrin Thedieck

Kathrin Thedieck

20

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Daryl P Shanley

Daryl P Shanley

19

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Peter Horvatovich

Peter Horvatovich

18

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author name string

Stefanie Ruf

2

1 reference

13 October 2017

Annika G Sonntag

3

1 reference

13 October 2017

Miriam Langelaar-Makkinje

4

1 reference

13 October 2017

Philip Hall

5

1 reference

13 October 2017

Patricia Razquin Navas

7

1 reference

13 October 2017

Karen van Eunen

8

1 reference

13 October 2017

Regine C Tölle

9

1 reference

13 October 2017

Jennifer J Schwarz

10

1 reference

13 October 2017

Heike Wiese

11

1 reference

13 October 2017

Jana Deitersen

13

1 reference

13 October 2017

Erik Fäßler

15

1 reference

13 October 2017

Sascha Schäuble

16

1 reference

13 October 2017

Udo Hahn

17

1 reference

13 October 2017

language of work or name

English

0 references

publication date

21 November 2016

1 reference

13 October 2017

Nature Communications

1 reference

13 October 2017

7

1 reference

13 October 2017

13254

1 reference

Creative Commons Attribution 4.0 International

13 October 2017

start time

21 November 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5121333/fullTextXML

inferred from PubMed Central ID database lookup

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5121333/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms13254

0 references

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Sestrin2 is a leucine sensor for the mTORC1 pathway

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Functional Proteomics Identifies Acinus L as a Direct Insulin- and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Substrate.

5 June 2018

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Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies

5 June 2018

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Quantitative phosphoproteomics reveals the protein tyrosine kinase Pyk2 as a central effector of olfactory receptor signaling in prostate cancer cells

5 June 2018

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Making new contacts: the mTOR network in metabolism and signalling crosstalk

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A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

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Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes.

5 June 2018

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Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-β (CaMKK-β)

5 June 2018

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AMP-activated protein kinase-α1 as an activating kinase of TGF-β-activated kinase 1 has a key role in inflammatory signals

5 June 2018

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The Genia Event and Protein Coreference tasks of the BioNLP Shared Task 2011

5 June 2018

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Autophagy and cell growth--the yin and yang of nutrient responses

5 June 2018

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mTOR signaling in growth control and disease

5 June 2018

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A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation

5 June 2018

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Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway

5 June 2018

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Ammonia-induced autophagy is independent of ULK1/ULK2 kinases

5 June 2018

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mTOR signaling in protein homeostasis: less is more?

5 June 2018

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Spatial coupling of mTOR and autophagy augments secretory phenotypes.

5 June 2018

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

5 June 2018

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The glutamate agonist homocysteine sulfinic acid stimulates glucose uptake through the calcium-dependent AMPK-p38 MAPK-protein kinase C zeta pathway in skeletal muscle cells

5 June 2018

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Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling

5 June 2018

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Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle

5 June 2018

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MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo

5 June 2018

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Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes

5 June 2018

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

5 June 2018

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The nuts and bolts of AGC protein kinases

5 June 2018

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mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action

5 June 2018

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5 June 2018

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Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood

5 June 2018

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Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

5 June 2018

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Signaling logic of activity-triggered dendritic protein synthesis: an mTOR gate but not a feedback switch

5 June 2018

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High-performance gene name normalization with GeNo

5 June 2018

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

5 June 2018

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MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

5 June 2018

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Interplay and effects of temporal changes in the phosphorylation state of serine-302, -307, and -318 of insulin receptor substrate-1 on insulin action in skeletal muscle cells

5 June 2018

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Dynamical modeling and multi-experiment fitting with PottersWheel

5 June 2018

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PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.

5 June 2018

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AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner

5 June 2018

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Data-based identifiability analysis of non-linear dynamical models

5 June 2018

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The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells

5 June 2018

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Leucine stimulates mammalian target of rapamycin signaling in C2C12 myoblasts in part through inhibition of adenosine monophosphate-activated protein kinase

5 June 2018

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COPASI--a COmplex PAthway SImulator

5 June 2018

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Activation of the extracellular calcium-sensing receptor initiates insulin secretion from human islets of Langerhans: involvement of protein kinases

5 June 2018

1 reference

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Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

5 June 2018

1 reference

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Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

5 June 2018

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

5 June 2018

1 reference

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Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5121333

IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5121333

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

5 June 2018

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BioNetGen: software for rule-based modeling of signal transduction based on the interactions of molecular domains

5 June 2018

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Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism

5 June 2018

1 reference

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Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling

5 June 2018

1 reference

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The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models

5 June 2018

1 reference

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Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomics

5 June 2018

1 reference

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The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha -dependent ERK-independent pathway

5 June 2018

1 reference

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L-amino acid sensing by the extracellular Ca2+-sensing receptor

5 June 2018

1 reference

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Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5121333

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5121333

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5121333

Mechanisms of receptor-mediated transmembrane communication

5 June 2018

1 reference

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Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program.

5 June 2018

1 reference

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A robust approach to extract biomedical events from literature.

18 August 2018

1 reference

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A modelling-experimental approach reveals insulin receptor substrate (IRS)-dependent regulation of adenosine monosphosphate-dependent kinase (AMPK) by insulin

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5121333

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5121333

Jun proteins are starvation-regulated inhibitors of autophagy

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5121333

Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5121333

Quantification of the effect of amino acids on an integrated mTOR and insulin signaling pathway.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5121333

A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5121333

Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5121333

Density functional computational studies on (E)-2-[(2-Hydroxy-5-nitrophenyl)-iminiomethyl]-4-nitrophenolate.

18 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS13254

A new look at the statistical model identification

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS13254

Autophosphorylation of the insulin receptor in vitro. Designation of phosphorylation sites and correlation with receptor kinase activation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27869123

12 December 2020

inferred from PubMed ID database lookup

Detection of mycoplasma in leukemia-lymphoma cell lines using polymerase chain reaction

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27869123

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NCOMMS13254

1 reference

13 October 2017

0 references

1 reference

13 October 2017

1 reference