A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation (Q39372532)

11 September 2017

A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation (English)

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11 September 2017

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Kathrin Thedieck

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author name string

Annika G Sonntag

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11 September 2017

Antje Thien

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11 September 2017

Mirja T Prentzell

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11 September 2017

Markus Gödel

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11 September 2017

Sven Fischer

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11 September 2017

Elke Neumann-Haefelin

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11 September 2017

Tobias B Huber

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11 September 2017

Ralf Baumeister

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11 September 2017

Daryl P Shanley

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11 September 2017

27 March 2012

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217

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ra25

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mTOR: from growth signal integration to cancer, diabetes and ageing

11 September 2017

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mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

21 January 2018

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Blocking the mTOR pathway: a drug discovery perspective

21 January 2018

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mTOR and the control of whole body metabolism

21 January 2018

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TOR complex 2: a signaling pathway of its own.

21 January 2018

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New inhibitors of the PI3K-Akt-mTOR pathway: insights into mTOR signaling from a new generation of Tor Kinase Domain Inhibitors (TORKinibs).

21 January 2018

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Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress

21 January 2018

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

21 January 2018

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Rag proteins regulate amino-acid-induced mTORC1 signalling.

21 January 2018

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Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor

21 January 2018

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

21 January 2018

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PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.

21 January 2018

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 January 2018

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PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

21 January 2018

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PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

21 January 2018

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The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

21 January 2018

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Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation

21 January 2018

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

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Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling

21 January 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

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Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

21 January 2018

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mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

21 January 2018

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

21 January 2018

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

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The nuts and bolts of AGC protein kinases

21 January 2018

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TOR regulation of AGC kinases in yeast and mammals

21 January 2018

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Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway

21 January 2018

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Dysregulation of the TSC-mTOR pathway in human disease

21 January 2018

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The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

21 January 2018

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A complex interplay between Akt, TSC2 and the two mTOR complexes

21 January 2018

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Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors

21 January 2018

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The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling

21 January 2018

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TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

21 January 2018

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mTORC2 is required for proliferation and survival of TSC2-null cells

21 January 2018

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PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis

21 January 2018

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Involvement of the cytoskeleton in controlling leading-edge function during chemotaxis

21 January 2018

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A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration

21 January 2018

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Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis

21 January 2018

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FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase

21 January 2018

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Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization

21 January 2018

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A comprehensive map of the mTOR signaling network

21 January 2018

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Signaling logic of activity-triggered dendritic protein synthesis: an mTOR gate but not a feedback switch

21 January 2018

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Mass and information feedbacks through receptor endocytosis govern insulin signaling as revealed using a parameter-free modeling framework.

21 January 2018

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The signaling petri net-based simulator: a non-parametric strategy for characterizing the dynamics of cell-specific signaling networks

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Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.

21 January 2018

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Model-based hypothesis testing of key mechanisms in initial phase of insulin signaling

21 January 2018

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Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation

21 January 2018

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Systems biology reveals new strategies for personalizing cancer medicine and confirms the role of PTEN in resistance to trastuzumab.

21 January 2018

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Ensemble modeling for analysis of cell signaling dynamics.

21 January 2018

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Models from experiments: combinatorial drug perturbations of cancer cells

21 January 2018

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A mathematical model of metabolic insulin signaling pathways

21 January 2018

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Quantification of the effect of amino acids on an integrated mTOR and insulin signaling pathway.

21 January 2018

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Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways

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21 January 2018

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21 January 2018

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Second AKT: the rise of SGK in cancer signalling

21 January 2018

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FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions

21 January 2018

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Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.

21 January 2018

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TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.

21 January 2018

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mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action

21 January 2018

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

21 January 2018

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

21 January 2018

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Rapamycin inhibits mTORC1, but not completely.

21 January 2018

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Improved semiquantitative Western blot technique with increased quantification range.

21 January 2018

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mu-Opioid receptor activates signaling pathways implicated in cell survival and translational control

21 January 2018

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Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

21 January 2018

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The segment polarity network is a robust developmental module

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Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

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21 January 2018

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p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils

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21 January 2018

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Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

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The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

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Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate

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Activation of mTORC2 by association with the ribosome

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Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis

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10.1126/SCISIGNAL.2002469

21 January 2018

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DOI

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11 September 2017

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