LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia (Q41885386)

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4 March 2020

title

LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia (English)

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4 March 2020

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Gabriela da Silva Xavier

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Marc Foretz

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Benoit Viollet

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Pedro Luis Herrera

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Frank Reimann

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Fiona Gribble

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Christophe Magnan

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Guy A. Rutter

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author name string

Gao Sun

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Tracy Gorman

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Claire Priest

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Antonia Solomou

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Helen Parker

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Stephanie Migrenne

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Anna Marley

15

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language of work or name

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31 January 2015

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4

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Beta cell connectivity in pancreatic islets: a type 2 diabetes target?

4 March 2020

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 beta cells

5 June 2018

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Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets

5 June 2018

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Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.

5 June 2018

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LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo

5 June 2018

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Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo

5 June 2018

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LKB1 regulates pancreatic beta cell size, polarity, and function

5 June 2018

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Insulin signaling in alpha cells modulates glucagon secretion in vivo

5 June 2018

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Regulating glucagon secretion: somatostatin in the spotlight

5 June 2018

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AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

5 June 2018

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mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer

5 June 2018

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Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains

5 June 2018

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Glucose-dependent regulation of gamma-aminobutyric acid (GABA A) receptor expression in mouse pancreatic islet alpha-cells.

5 June 2018

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Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells

5 June 2018

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Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro

5 June 2018

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AMP-activated protein kinase signaling in metabolic regulation

5 June 2018

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Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

5 June 2018

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Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

5 June 2018

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Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells.

5 June 2018

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Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver

5 June 2018

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5 June 2018

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

5 June 2018

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5 June 2018

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5 June 2018

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Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression

5 June 2018

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The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity

5 June 2018

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Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

5 June 2018

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Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression

5 June 2018

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Impact of lack of suppression of glucagon on glucose tolerance in humans

5 June 2018

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Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired alpha-cell responses in type 1 diabetes.

5 June 2018

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A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

5 June 2018

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5 June 2018

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Studies of pancreatic alpha cell function in normal and diabetic subjects

5 June 2018

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Effects of vagal stimulation on glucagon and insulin secretion.

5 June 2018

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The Influence of γ-Aminobutyric Acid on Hormone Release by the Mouse and Rat Endocrine Pancreas*

5 June 2018

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Regulation of net hepatic glucose uptake in vivo

5 June 2018

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Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice

5 June 2018

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The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells.

18 August 2018

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Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse

18 August 2018

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Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release

18 August 2018

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Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis

18 August 2018

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A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic alpha-cell

18 August 2018

1 reference

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Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells.

18 August 2018

1 reference

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Regulation of glucagon release in mouse -cells by KATP channels and inactivation of TTX-sensitive Na+ channels.

18 August 2018

1 reference

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Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

18 August 2018

1 reference

12 December 2020

Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia

1 reference

12 December 2020

Author Correction: Beta cell connectivity in pancreatic islets: a type 2 diabetes target?

1 reference

12 December 2020

Sympathetic nerve stimulation versus pancreatic norepinephrine infusion in the dog: 1). Effects on basal release of insulin and glucagon

1 reference

12 December 2020

10.1016/J.MOLMET.2015.01.006

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