Inhibition of L-carnitine biosynthesis and transport by methyl-γ-butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction (Q41861087)

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scientific article published on 12 January 2015

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English	Inhibition of L-carnitine biosynthesis and transport by methyl-γ-butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction	scientific article published on 12 January 2015

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scholarly article

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Europe PubMed Central

13 October 2017

Inhibition of L-carnitine biosynthesis and transport by methyl-γ-butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction (English)

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Europe PubMed Central

13 October 2017

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Reinis Vilskersts

4

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Osvalds Pugovics

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7 June 2020

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E Liepinsh

1

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7 June 2020

M Makrecka-Kuka

2

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7 June 2020

J Kuka

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E Makarova

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H Cirule

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E Loza

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D Lola

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S Grinberga

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I Kalvins

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M Dambrova

12

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publication date

12 January 2015

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British Journal of Pharmacology

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7 June 2020

172

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1319-1332

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7 June 2020

Targeting carnitine biosynthesis: discovery of new inhibitors against γ-butyrobetaine hydroxylase

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Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis

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The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine

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Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats

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Modulation of myocardial metabolism: an emerging therapeutic principle.

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The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats

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Myocardial fatty acid metabolism in health and disease

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Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation

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Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats

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Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells

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Different effects of palmitoyl-L-carnitine and palmitoyl-CoA on mitochondrial function in rat ventricular myocytes

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Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction

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Mildronate, a novel fatty acid oxidation inhibitor and antianginal agent, reduces myocardial infarct size without affecting hemodynamics

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Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation

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Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation

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Mildronate: cardioprotective action through carnitine-lowering effect

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The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase

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5 June 2018

Selective inhibition of OCTN2 is more effective than inhibition of gamma-butyrobetaine dioxygenase to decrease the availability of l-carnitine and to reduce myocardial infarct size.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337704

18 August 2018

Mildronate, the inhibitor of L-carnitine transport, induces brain mitochondrial uncoupling and protects against anoxia-reoxygenation.

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18 August 2018

Mildronate treatment alters γ-butyrobetaine and l-carnitine concentrations in healthy volunteers.

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Effect of inhibiting carnitine biosynthesis on male rat sexual performance.

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Dissociation between metabolic and efficiency effects of perhexiline in normoxic rat myocardium.

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18 August 2018

Fatty acid oxidation and related gene expression in heart depleted of carnitine by mildronate treatment in the rat.

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18 August 2018

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Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion

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12 December 2020

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Glucose oxidation is stimulated in reperfused ischemic hearts with the carnitine palmitoyltransferase 1 inhibitor, Etomoxir

1 reference

https://pubmed.ncbi.nlm.nih.gov/25363063

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/25363063

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac diacylglycerol accumulation in high fat-fed mice is associated with impaired insulin-stimulated glucose oxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25363063

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/25363063

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/BPH.13004

1 reference

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7 June 2020

1 reference

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7 June 2020

1 reference

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7 June 2020

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