Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5 (Q41848329)

13 October 2017

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5 (English)

1 reference

13 October 2017

David Smil

9

0 references

Peter J. Brown

object named as

Peter J Brown

18

0 references

Cheryl Arrowsmith

object named as

Cheryl H Arrowsmith

21

0 references

Dalia Barsyte-Lovejoy

5

object named as

Dalia Barsyte-Lovejoy

1 reference

13 October 2017

4

Gregory A Wasney

1 reference

13 October 2017

11

Taraneh Hajian

1 reference

13 October 2017

Guillermo Senisterra

1

1 reference

13 October 2017

Hong Wu

2

1 reference

13 October 2017

Abdellah Allali-Hassani

3

1 reference

13 October 2017

Ludmila Dombrovski

6

1 reference

13 October 2017

Aiping Dong

7

1 reference

13 October 2017

Kong T Nguyen

8

1 reference

13 October 2017

Yuri Bolshan

10

1 reference

13 October 2017

Hao He

12

1 reference

13 October 2017

Alma Seitova

13

1 reference

13 October 2017

Irene Chau

14

1 reference

13 October 2017

Fengling Li

15

1 reference

13 October 2017

Gennadiy Poda

16

1 reference

13 October 2017

Jean-François Couture

17

1 reference

13 October 2017

Rima Al-Awar

19

1 reference

13 October 2017

Matthieu Schapira

20

1 reference

13 October 2017

Masoud Vedadi

22

1 reference

13 October 2017

language of work or name

English

0 references

publication date

1 January 2013

1 reference

13 October 2017

9

1 reference

based on heuristic

inferred from page(s)

published in

Biochemical Journal

1 reference

13 October 2017

449

1 reference

13 October 2017

1

1 reference

13 October 2017

151-159

1 reference

Creative Commons Attribution-NonCommercial 2.5 Generic

13 October 2017

start time

25 July 2019

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

The pathogenesis of mixed-lineage leukemia

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Fluorescence-based methods for screening writers and readers of histone methyl marks

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Structural and biochemical insights into MLL1 core complex assembly

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Mechanisms of leukemogenesis by MLL fusion proteins

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Characterization of a Novel WDR5-binding Site That Recruits RbBP5 through a Conserved Motif to Enhance Methylation of Histone H3 Lysine 4 by Mixed Lineage Leukemia Protein-1

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

MolProbity: all-atom structure validation for macromolecular crystallography

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Therapeutic targeting of MLL.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Arginine methylation of the histone H3 tail impedes effector binding

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

MLL translocations, histone modifications and leukaemia stem-cell development

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Hox genes in hematopoiesis and leukemogenesis.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Structural basis for molecular recognition and presentation of histone H3 by WDR5

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Regulation of MLL1 H3K4 methyltransferase activity by its core components

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Coot: model-building tools for molecular graphics

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Refinement of macromolecular structures by the maximum-likelihood method

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Translating the Histone Code

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Histone methylation versus histone acetylation: new insights into epigenetic regulation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

WDR5, a complexed protein.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517986

SFCHECK: a unified set of procedures for evaluating the quality of macromolecular structure-factor data and their agreement with the atomic model

18 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1042%2FBJ20121280

Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22989411

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1042/BJ20121280

1 reference

13 October 2017

1 reference

13 October 2017

1 reference