Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53. (Q41792117)

10 October 2017

Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53. (English)

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Hsp90 family chaperone HSP82 YPL240C

10 October 2017

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GOA release 2020-03-11

Franz Hagn

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Klaus Richter

object named as

Klaus Richter

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author name string

Stephan Lagleder

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10 October 2017

Marco Retzlaff

3

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10 October 2017

Julia Rohrberg

4

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10 October 2017

Oliver Demmer

5

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10 October 2017

Johannes Buchner

7

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10 October 2017

Horst Kessler

8

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10 October 2017

4 September 2011

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Nature Structural & Molecular Biology

10 October 2017

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10 October 2017

18

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10 October 2017

10

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10 October 2017

1086-1093

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https://scigraph.springernature.com/pub.10.1038/nsmb.2114

10 October 2017

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cites work

Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex

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Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements

21 January 2018

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The Hsp90 chaperone machinery

21 January 2018

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Substrate transfer from the chaperone Hsp70 to Hsp90.

21 January 2018

1 reference

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

21 January 2018

1 reference

The middle domain of Hsp90 acts as a discriminator between different types of client proteins

21 January 2018

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Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

21 January 2018

1 reference

Mutational analysis of Hsp90 function: interactions with a steroid receptor and a protein kinase

21 January 2018

1 reference

The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site

21 January 2018

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Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90.

21 January 2018

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The client protein p53 adopts a molten globule-like state in the presence of Hsp90.

21 January 2018

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CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90.

21 January 2018

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Substrate binding drives large-scale conformational changes in the Hsp90 molecular chaperone

21 January 2018

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p53--a natural cancer killer: structural insights and therapeutic concepts

21 January 2018

1 reference

T antigen is bound to a host protein in SY40-transformed cells

21 January 2018

1 reference

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

21 January 2018

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Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

21 January 2018

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Phosphorylation and hsp90 binding mediate heat shock stabilization of p53

21 January 2018

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HSP90 and the chaperoning of cancer

21 January 2018

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Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures

21 January 2018

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Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell

21 January 2018

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The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent

21 January 2018

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Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors

21 January 2018

1 reference

Conserved conformational changes in the ATPase cycle of human Hsp90.

21 January 2018

1 reference

NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol

21 January 2018

1 reference

Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone

21 January 2018

1 reference

TROSY in triple-resonance experiments: new perspectives for sequential NMR assignment of large proteins

21 January 2018

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Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery

21 January 2018

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Mechanism of coupled folding and binding of an intrinsically disordered protein

21 January 2018

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Hot-spot mutants of p53 core domain evince characteristic local structural changes.

21 January 2018

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Utilization of site-directed spin labeling and high-resolution heteronuclear nuclear magnetic resonance for global fold determination of large proteins with limited nuclear overhauser effect data

21 January 2018

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Validation of Protein Structure from Anisotropic Carbonyl Chemical Shifts in a Dilute Liquid Crystalline Phase

21 January 2018

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BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain

21 January 2018

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WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.

21 January 2018

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Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53.

21 January 2018

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Charge-rich regions modulate the anti-aggregation activity of Hsp90.

21 January 2018

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ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein

21 January 2018

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Structure of an Hsp90-Cdc37-Cdk4 complex.

21 January 2018

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Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine

21 January 2018

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Unliganded and hormone-bound glucocorticoid receptors interact with distinct hydrophobic sites in the Hsp90 C-terminal domain

21 January 2018

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A hydrophobic segment within the C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone

21 January 2018

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A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

21 January 2018

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Sti1 is a non-competitive inhibitor of the Hsp90 ATPase. Binding prevents the N-terminal dimerization reaction during the atpase cycle

21 January 2018

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Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence

21 January 2018

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The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs.

21 January 2018

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Preparative scale expression of membrane proteins in Escherichia coli-based continuous exchange cell-free systems.

21 January 2018

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SEDVIEW, real-time sedimentation analysis.

21 January 2018

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Automated backbone assignment of labeled proteins using the threshold accepting algorithm.

21 January 2018

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Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution

21 January 2018

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Direct measurement of distances and angles in biomolecules by NMR in a dilute liquid crystalline medium

21 January 2018

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Tunable alignment of macromolecules by filamentous phage yields dipolar coupling interactions

21 January 2018

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The Xplor-NIH NMR molecular structure determination package

21 January 2018

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The HADDOCK web server for data-driven biomolecular docking

21 January 2018

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HYDRONMR: prediction of NMR relaxation of globular proteins from atomic-level structures and hydrodynamic calculations.

21 January 2018

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Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients

21 January 2018

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The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association

21 January 2018

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Cooperative binding of p53 to DNA: regulation by protein-protein interactions through a double salt bridge

31 March 2020

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Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NSMB.2114

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Dimensions Publication ID

10 October 2017

1021694801

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Fatcat ID

release_bdatvqv2njelhadgvdkrtr5q2u

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Fatcat

https://api.fatcat.wiki/v0/release/bdatvqv2njelhadgvdkrtr5q2u

mapped directly with Wikidata item

24 November 2022

based on heuristic

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