BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain (Q33661720)

28 July 2017

BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain (English)

1 reference

28 July 2017

Franz Hagn

1

1 reference

28 July 2017

Christian Klein

2

1 reference

28 July 2017

Oliver Demmer

3

1 reference

28 July 2017

Natasha Marchenko

4

1 reference

28 July 2017

Angelina Vaseva

5

1 reference

28 July 2017

Ute M Moll

6

1 reference

28 July 2017

Horst Kessler

7

1 reference

28 July 2017

language of work or name

English

0 references

publication date

2 December 2009

1 reference

28 July 2017

12

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

1 reference

28 July 2017

285

1 reference

28 July 2017

3439-3450

1 reference

28 July 2017

5

1 reference

p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity

28 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Detecting folding motifs and similarities in protein structures

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Classic and novel roles of p53: prospects for anticancer therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Selective tumor cell targeting using low-affinity, multivalent interactions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

p53--a natural cancer killer: structural insights and therapeutic concepts

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Solution structure of p53 core domain: structural basis for its instability

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

UCSF Chimera--a visualization system for exploratory research and analysis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Defining the p53 DNA-binding domain/Bcl-x(L)-binding interface using NMR.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

p53 has a direct apoptogenic role at the mitochondria

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

HADDOCK: a protein-protein docking approach based on biochemical or biophysical information

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

The Xplor-NIH NMR molecular structure determination package

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Apoptosis: a link between cancer genetics and chemotherapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Utilization of site-directed spin labeling and high-resolution heteronuclear nuclear magnetic resonance for global fold determination of large proteins with limited nuclear overhauser effect data

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Tunable alignment of macromolecules by filamentous phage yields dipolar coupling interactions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Measurement of J and dipolar couplings from simplified two-dimensional NMR spectra

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Bax directly induces release of cytochrome c from isolated mitochondria

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Discovering high-affinity ligands for proteins: SAR by NMR

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

The inoculum effect with gram-negative bacteria in vitro and in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Stability of proteins: small globular proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823462

Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL.

21 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.065391

In vitro folding and characterization of the p53 DNA binding domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.065391

NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.065391

2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.065391

Ligands for mapping alphavbeta3-integrin expression in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.065391

Cooperative binding of p53 to DNA: regulation by protein-protein interactions through a double salt bridge

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19955567

12 December 2020

inferred from PubMed ID database lookup

Cell biology. Cellular demolition and the rules of engagement

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19955567

12 December 2020

inferred from PubMed ID database lookup

Pharmacological rescue of mutant p53 conformation and function

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19955567

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M109.065391

1 reference

28 July 2017

1 reference

28 July 2017

1 reference