The impact of hypoxia on tumor-associated macrophages (Q41678839)

7 October 2017

1 reference

title

The impact of hypoxia on tumor-associated macrophages (English)

1 reference

7 October 2017

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2

1 reference

7 October 2017

Anne-Theres Henze

1

1 reference

PMCID

5096805

7 October 2017

language of work or name

English

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publication date

2 August 2016

1 reference

Journal of Clinical Investigation

7 October 2017

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7 October 2017

126

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7 October 2017

10

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7 October 2017

3672-3679

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Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis

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1 reference

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1 reference

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1 reference

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Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

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Macrophages and therapeutic resistance in cancer

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Environment drives selection and function of enhancers controlling tissue-specific macrophage identities

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1 reference

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6 June 2018

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6 June 2018

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The immune microenvironment confers resistance to MAPK pathway inhibitors through macrophage-derived TNFα

6 June 2018

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CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.

6 June 2018

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Macrophages are recruited to hypoxic tumor areas and acquire a pro-angiogenic M2-polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin

6 June 2018

1 reference

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Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.

6 June 2018

1 reference

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6 June 2018

1 reference

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6 June 2018

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Retracted: Macrophage Colony-Stimulating Factor Augments Tie2-Expressing Monocyte Differentiation, Angiogenic Function, and Recruitment in a Mouse Model of Breast Cancer

6 June 2018

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Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.

6 June 2018

1 reference

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6 June 2018

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CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer

6 June 2018

1 reference

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Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses

6 June 2018

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Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors

6 June 2018

1 reference

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A lineage of myeloid cells independent of Myb and hematopoietic stem cells

6 June 2018

1 reference

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Regulation of macrophage function by adenosine

6 June 2018

1 reference

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Macrophage plasticity and polarization: in vivo veritas

6 June 2018

1 reference

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Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment

6 June 2018

1 reference

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Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy

6 June 2018

1 reference

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Adenosine promotes alternative macrophage activation via A2A and A2B receptors

6 June 2018

1 reference

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Targeting hypoxia in cancer therapy

6 June 2018

1 reference

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CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans

6 June 2018

1 reference

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6 June 2018

Hypoxia and inflammation

1 reference

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HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF

6 June 2018

1 reference

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Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophages

6 June 2018

1 reference

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Fate mapping analysis reveals that adult microglia derive from primitive macrophages

6 June 2018

1 reference

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Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression

6 June 2018

1 reference

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Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation

6 June 2018

1 reference

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Phagocyte partnership during the onset and resolution of inflammation.

6 June 2018

1 reference

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Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis

6 June 2018

1 reference

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The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer

6 June 2018

1 reference

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Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy.

6 June 2018

1 reference

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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

6 June 2018

1 reference

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Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway.

6 June 2018

1 reference

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6 June 2018

1 reference

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Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1.

6 June 2018

1 reference

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M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

6 June 2018

1 reference

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Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

6 June 2018

1 reference

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Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

6 June 2018

1 reference

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Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer

6 June 2018

1 reference

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Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia

6 June 2018

1 reference

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Central role of Sp1-regulated CD39 in hypoxia/ischemia protection

6 June 2018

1 reference

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Immunogenic cancer cell death: a key-lock paradigm

6 June 2018

1 reference

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HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

6 June 2018

1 reference

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Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms

6 June 2018

1 reference

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Macrophage activation by endogenous danger signals

6 June 2018

1 reference

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Drug resistance and the solid tumor microenvironment

6 June 2018

1 reference

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HIF-dependent induction of adenosine A2B receptor in hypoxia

6 June 2018

1 reference

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Molecular mechanisms of action of bisphosphonates: current status.

6 June 2018

1 reference

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Drug penetration in solid tumours

6 June 2018

1 reference

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Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia.

6 June 2018

1 reference

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B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

6 June 2018

1 reference

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Distinct role of macrophages in different tumor microenvironments

6 June 2018

1 reference

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Colony-stimulating factor-1 in immunity and inflammation.

6 June 2018

1 reference

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HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Macrophage migration and gene expression in response to tumor hypoxia

6 June 2018

1 reference

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Macrophages direct tumour histology and clinical outcome in a colon cancer model

6 June 2018

1 reference

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Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop

6 June 2018

1 reference

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The chemokine system in diverse forms of macrophage activation and polarization

6 June 2018

1 reference

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Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

6 June 2018

1 reference

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Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Hypoxia inhibits the expression of the CCR5 chemokine receptor in macrophages

6 June 2018

1 reference

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A role for endothelin-2 and its receptors in breast tumor cell invasion

6 June 2018

1 reference

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Treatment of murine hepatocellular carcinoma using genetically modified cells to express interleukin-12.

6 June 2018

1 reference

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Tumour-educated macrophages promote tumour progression and metastasis

6 June 2018

1 reference

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Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy

6 June 2018

1 reference

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6 June 2018

1 reference

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Alternative activation of macrophages

6 June 2018

1 reference

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Regulation of EMAP II by hypoxia

6 June 2018

1 reference

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Hypoxia signaling to genes: significance in Alzheimer's disease

6 June 2018

1 reference

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Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia

6 June 2018

1 reference

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Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors

6 June 2018

1 reference

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Hypoxia--a key regulatory factor in tumour growth

6 June 2018

1 reference

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Angiogenesis in cancer and other diseases

6 June 2018

1 reference

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M-1/M-2 macrophages and the Th1/Th2 paradigm

6 June 2018

1 reference

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HIF-1: mediator of physiological and pathophysiological responses to hypoxia

6 June 2018

1 reference

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Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma

6 June 2018

1 reference

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Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain

6 June 2018

1 reference

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Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs

6 June 2018

1 reference

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Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast

6 June 2018

1 reference

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Oxygen-sensitive ion channels

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Chemically induced hypotension increases PGE2 release and depresses macrophage antigen presentation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Synergistic effect of acute hypoxia on flow-induced release of ATP from cultured endothelial cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

6 June 2018

1 reference

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The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Activated macrophages induce vascular proliferation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Mechanisms of hypoxia-mediated immune escape in cancer.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Stromal macrophage expressing CD204 is associated with tumor aggressiveness in lung adenocarcinoma.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

High macrophage infiltration along the tumor front correlates with improved survival in colon cancer.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Regulation of macrophage production of vascular endothelial growth factor (VEGF) by hypoxia and transforming growth factor beta-1.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Tumor growth increases Ia- macrophage synthesis of tumor necrosis factor-alpha and prostaglandin E2: changes in macrophage suppressor activity.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

An Address on the Value of Pathological Experiments

2 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5096805

Correlation of histological localization of tumor-associated macrophages with clinicopathological features in endometrial cancer

2 December 2018

1 reference

12 December 2020

Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes

1 reference

12 December 2020

Hypoxic Regulation of Lactate Dehydrogenase A

1 reference

12 December 2020

Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas

1 reference

12 December 2020

Hypoxia-induced, perinecrotic expression of endothelial Per-ARNT-Sim domain protein-1/hypoxia-inducible factor-2alpha correlates with tumor progression, vascularization, and focal macrophage infiltration in bladder cancer

1 reference

12 December 2020

A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors

1 reference

12 December 2020

CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer

1 reference

12 December 2020

Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells

1 reference

12 December 2020

The degree of macrophage infiltration into the cancer cell nest is a significant predictor of survival in gastric cancer patients

1 reference

12 December 2020

Autocrine Production of IL-10 Mediates Defective IL-12 Production and NF- B Activation in Tumor-Associated Macrophages

1 reference

12 December 2020

Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI84427

1 reference

7 October 2017

1 reference

7 October 2017

1 reference

PMCID

5096805