ARQiv-HTS, a versatile whole-organism screening platform enabling in vivo drug discovery at high-throughput rates. (Q41496032)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

title

ARQiv-HTS, a versatile whole-organism screening platform enabling in vivo drug discovery at high-throughput rates (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

0 references

1 reference

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

author name string

David T White

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Arife Unal Eroglu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Guohua Wang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Liyun Zhang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Sumitra Sengupta

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Ding Ding

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Surendra K Rajpurohit

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Steven L Walker

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Hongkai Ji

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Jiang Qian

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

publication date

10 November 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

page(s)

2432-2453

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nprot.2016.142

27 March 2020

exact match

0 references

cites work

Zebrafish as tools for drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass.

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

From phenotype to mechanism after zebrafish small molecule screens.

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

The fickle P value generates irreproducible results

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

15 years of zebrafish chemical screening

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

An ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegans

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Advances in zebrafish chemical screening technologies.

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Interference with xenobiotic metabolic activity by the commonly used vehicle solvents dimethylsulfoxide and methanol in zebrafish (Danio rerio) larvae but not Daphnia magna

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Diagnosing the decline in pharmaceutical R&D efficiency

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Automated reporter quantification in vivo: high-throughput screening method for reporter-based assays in zebrafish

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

A new system for the rapid collection of large numbers of developmentally staged zebrafish embryos

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Large-scale assessment of the zebrafish embryo as a possible predictive model in toxicity testing

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

How were new medicines discovered?

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Automated feature detection and imaging for high-resolution screening of zebrafish embryos

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Illustration of SSMD, z score, SSMD*, z* score, and t statistic for hit selection in RNAi high-throughput screens

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Multicolor time-lapse imaging of transgenic zebrafish: visualizing retinal stem cells activated by targeted neuronal cell ablation

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

A chemical genetic screen in zebrafish for pathways interacting with cdx4 in primitive hematopoiesis

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Inhibition of histone deacetylase expands the renal progenitor cell population

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Chemical screening for hair cell loss and protection in the zebrafish lateral line

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Rapid behavior-based identification of neuroactive small molecules in the zebrafish

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Ha-ras oncogene-induced Stat3 phosphorylation enhances oncogenicity of the cell

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Novel analytic criteria and effective plate designs for quality control in genome-scale RNAi screens

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Integrating experimental and analytic approaches to improve data quality in genome-wide RNAi screens

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Generation of FGF reporter transgenic zebrafish and their utility in chemical screens.

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

A pair of new statistical parameters for quality control in RNA interference high-throughput screening assays

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Chemical genetics suggests a critical role for lysyl oxidase in zebrafish notochord morphogenesis

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Small molecule screening in the zebrafish

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Small molecules that delay S phase suppress a zebrafish bmyb mutant

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Zebrafish: a new model on the pharmaceutical catwalk

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Nonleadlikeness and leadlikeness in biochemical screening

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Small molecule developmental screens reveal the logic and timing of vertebrate development

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Robust adaptive phase-shifting demodulation for testing moving wavefronts.

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Image-based fluidic sorting system for automated Zebrafish egg sorting into multiwell plates.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

High-throughput assay for small molecules that modulate zebrafish embryonic heart rate.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Comparative embryotoxicity and proteotoxicity of three carrier solvents to zebrafish (Danio rerio) embryos

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

Drugs that induce repolarization abnormalities cause bradycardia in zebrafish

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568077

19 August 2018

Identifiers

DOI

10.1038/NPROT.2016.142

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27831568%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

1 reference