Towards a unified model of tumor suppression: lessons learned from the human patched gene (Q41462850)

1 October 2017

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title

Towards a unified model of tumor suppression: lessons learned from the human patched gene (English)

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1 October 2017

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1

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PubMed ID

9141460

1 October 2017

language of work or name

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1 April 1997

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Biochimica et Biophysica Acta

1 October 2017

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1 October 2017

1332

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1 October 2017

2

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1 October 2017

M43-52

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Mutation and cancer: statistical study of retinoblastoma

1 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

The molecular basis of oncogenes and tumor suppressor genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

The retinoblastoma protein and cell cycle control

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Mutations affecting segment number and polarity in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

The genetic basis of patterned baldness in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

1 reference

7 January 2021

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Phosphorylation of the fused protein kinase in response to signaling from hedgehog

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

The Drosophila patched gene encodes a putative membrane protein required for segmental patterning

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https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

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https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Role of the Drosophila patched gene in positional signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Signalling by hedgehog family proteins in Drosophila and vertebrate development

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Two Cytoplasmic Domains of Mammalian Adenylyl Cyclase Form a G- and Forskolin-activated Enzymein Vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Identification of an amplified, highly expressed gene in a human glioma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Identification of FAP locus genes from chromosome 5q21

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Identification and characterization of the familial adenomatous polyposis coli gene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Polarity, proliferation and the hedgehog pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

A two-hit model for developmental defects in Gorlin syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Microsatellite analysis of loss of heterozygosity on chromosomes 9q, 11p and 17p in medulloblastomas

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Association of the APC tumor suppressor protein with catenins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Association of the APC gene product with beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Regulating cell proliferation: as easy as APC.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

The TGF-beta family and its composite receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Tumor suppressor genes in the TGF-beta signaling pathway?

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

TGFbeta signaling: receptors, transducers, and Mad proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

A human Mad protein acting as a BMP-regulated transcriptional activator

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Mad-related genes in the human

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

G1 events and regulation of cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Inhibitors of mammalian G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Role of the INK4a locus in tumor suppression and cell mortality.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Multiple nevoid basal-cell epithelioma, jaw cysts and bifid rib. A syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Ras signaling and NF1.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Inhibition of transcription elongation by the VHL tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Granin expectations in breast cancer?

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Molecular epidemiology of basal cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Tamoxifen: teaching an old drug new tricks?

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Protein kinase A and hedgehog signaling in Drosophila limb development

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2896%2900043-1

7 January 2021

10.1016/S0304-419X(96)00043-1

Identifiers

DOI

1 reference

1 October 2017

1 reference

PubMed ID

9141460