The 3' UTR of FMR1 mRNA is a target of miR-101, miR-129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse (Q41412994)

30 September 2017

The 3' UTR of FMR1 mRNA is a target of miR-101, miR-129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse (English)

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30 September 2017

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30 September 2017

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30 September 2017

Simona D'Antoni

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Renate K Hukema

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Renate Hukema

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Maria Vincenza Catania

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Maria Vincenza Catania

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author name string

Samantha Zongaro

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30 September 2017

Laetitia Davidovic

4

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30 September 2017

Rob Willemsen

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30 September 2017

Barbara Bardoni

9

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30 September 2017

5 February 2013

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30 September 2017

Human Molecular Genetics

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30 September 2017

22

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30 September 2017

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30 September 2017

1971-1982

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Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function

30 September 2017

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Intellectual disabilities, neuronal posttranscriptional RNA metabolism, and RNA-binding proteins: three actors for a complex scenario.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Perturbation of dendritic protrusions in intellectual disability

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

FXTAS: a progressive neurologic syndrome associated with Fragile X premutation

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

CGG repeat in the FMR1 gene: size matters

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Fragile-X-associated tremor/ataxia syndrome (FXTAS) in females with the FMR1 premutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

FMR1 premutation and full mutation molecular mechanisms related to autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Neuropathology of fragile X-associated tremor/ataxia syndrome (FXTAS).

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Protein composition of the intranuclear inclusions of FXTAS.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Widespread non-central nervous system organ pathology in fragile X premutation carriers with fragile X-associated tremor/ataxia syndrome and CGG knock-in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

CGG-repeat length threshold for FMR1 RNA pathogenesis in a cellular model for FXTAS

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Premutation CGG-repeat expansion of the Fmr1 gene impairs mouse neocortical development.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Cognitive decline, neuromotor and behavioural disturbances in a mouse model for fragile-X-associated tremor/ataxia syndrome (FXTAS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Progressive spatial processing deficits in a mouse model of the fragile X premutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

MicroRNAs in stress signaling and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

A brain-specific microRNA regulates dendritic spine development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

A novel function for fragile X mental retardation protein in translational activation

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Scan-statistic approach identifies clusters of rare disease variants in LRP2, a gene linked and associated with autism spectrum disorders, in three datasets

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Combination of linkage mapping and microarray-expression analysis identifies NF-kappaB signaling defect as a cause of autosomal-recessive mental retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Cellular anatomy, physiology and epileptiform activity in the CA3 region of Dcx knockout mice: a neuronal lamination defect and its consequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

MiRonTop: mining microRNAs targets across large scale gene expression studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Novel repressor of the human FMR1 gene - identification of p56 human (GCC)(n)-binding protein as a Krüppel-like transcription factor ZF5

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Differential usage of transcriptional start sites and polyadenylation sites in FMR1 premutation alleles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

FRAXE-associated mental retardation protein (FMR2) is an RNA-binding protein with high affinity for G-quartet RNA forming structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

A metabolomic and systems biology perspective on the brain of the fragile X syndrome mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

A microdeletion in Xp11.3 accounts for co-segregation of retinitis pigmentosa and mental retardation in a large kindred.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Disrupted microRNA expression caused by Mecp2 loss in a mouse model of Rett syndrome

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Postnatal inactivation reveals enhanced requirement for MeCP2 at distinct age windows

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Effect of (S)-3,5-DHPG on microRNA expression in mouse brain

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

The nuclear envelope can control gene expression and cell cycle progression via miRNA regulation.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Fibroblast phenotype in male carriers of FMR1 premutation alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Evolution under canalization and the dual roles of microRNAs: a hypothesis

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Evolution of microRNA diversity and regulation in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Abnormal dendrite and spine morphology in primary visual cortex in the CGG knock-in mouse model of the fragile X premutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

The many faces of α-synuclein: from structure and toxicity to therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Suppression of the intrinsic apoptosis pathway by synaptic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Analysis of transcriptional codes for zebrafish dopaminergic neurons reveals essential functions of Arx and Isl1 in prethalamic dopaminergic neuron development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Cholinergic dysfunction contributes to gait disturbance in early Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Transcriptional activation of p62/A170/ZIP during the formation of the aggregates: possible mechanisms and the role in Lewy body formation in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

FMRP interferes with the Rac1 pathway and controls actin cytoskeleton dynamics in murine fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Real-time quantification of microRNAs by stem-loop RT-PCR

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

MiR-129-5p is required for histone deacetylase inhibitor-induced cell death in thyroid cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT044

21 January 2018

Identifiers

DOI

10.1093/HMG/DDT044

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30 September 2017

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